Reactome: A Curated Pathway Database

SMURF1/2 ubiquitinates PTCH1

Stable Identifier
R-HSA-5632648
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

SMURF 1 and 2 are required in a redundant manner for the ligand-dependent ubiquitination of the C-terminal tail of PTCH. Ubiquitination is required for PTCH1 clearance from the primary cilium to endocytic compartments for degradation, allowing downstream pathway activation (Rohatgi et al, 2007; Yue et al, 2014; Huang et al, 2013).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
ubiquitin protein ligase activity of PTCH1:SMURF [ciliary membrane] PTCH1:SMURF [ciliary membrane] ubiquitin protein ligase activity (0061630)
Inferred From