PTCH is internalized

Stable Identifier
Reaction [BlackBoxEvent]
Homo sapiens
Locations in the PathwayBrowser

After SMURF-dependent ubiquitination, PTCH1 is internalized to endocytic vesicles for degradation (Rohatgi et al, 2007; Huang et al, 2013; Yue et al, 2014). PTCH1 and SMO show reciprocal changes in localization upon Hh pathway activation, with PTCH moving from the primary cilium to internal vesicles while SMO becomes enriched in the primary cilium after ligand binding (Denef et al, 2000; Rohatgi et al, 2007; Corbit et al, 2005; Kovacs et al, 2008; reviewed in Goetz and Anderson). In mice, internalization of PTCH1 appears to be independent of SMO, while in flies, activated SMO is required to promote the SMURF-dependent downregulation of PTCH (Yue et al, 2014; Huang et al, 2013).

Participant Of
Orthologous Events