Reactome | p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4

p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4

Stable Identifier

R-HSA-5632732

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4

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Phosphorylation of TSC2 by AKT enables association of TSC2 with 14-3-3 proteins YWHAB (14-3-3 protein beta/alpha), YWHAQ (14-3-3 protein theta), YWHAG (14-3-3 protein gamma), YWHAH (14-3-3 protein eta), YWHAE (14-3-3 protein epsilon), YWHAZ (14-3-3 protein zeta/delta) or SFN (14-3-3 protein sigma) (Liu et al. 2002). Binding to 14-3-3 proteins sequesters TSC2 to the cytosol and prevents its association with TSC1 (Cai et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
12438239	14-3-3 interacts with the tumor suppressor tuberin at Akt phosphorylation site(s) Liu, MY, Walker, CL, Bedford, MT, Cai, S, Espejo, A	Cancer Res.	2002
16636147	Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning Kim, J, Guo, R, Walker, CL, Shen, J, Kiguchi, K, Cai, SL, Short, JD, Tee, AR, Bergeron, JM, Johnson, CL	J. Cell Biol.	2006