p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4

Stable Identifier
R-HSA-5632732
Type
Reaction
Species
Homo sapiens
Compartment
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Phosphorylation of TSC2 by AKT enables association of TSC2 with 14-3-3 proteins YWHAB (14-3-3 protein beta/alpha), YWHAQ (14-3-3 protein theta), YWHAG (14-3-3 protein gamma), YWHAH (14-3-3 protein eta), YWHAE (14-3-3 protein epsilon), YWHAZ (14-3-3 protein zeta/delta) or SFN (14-3-3 protein sigma) (Liu et al. 2002). Binding to 14-3-3 proteins sequesters TSC2 to the cytosol and prevents its association with TSC1 (Cai et al. 2006).

Literature References
PubMed ID Title Journal Year
16636147 Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning

Cai, SL, Tee, AR, Short, JD, Bergeron, JM, Kim, J, Shen, J, Guo, R, Johnson, CL, Kiguchi, K, Walker, CL

J. Cell Biol. 2006
12438239 14-3-3 interacts with the tumor suppressor tuberin at Akt phosphorylation site(s)

Liu, MY, Cai, S, Espejo, A, Bedford, MT, Walker, CL

Cancer Res. 2002
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