Binding of TP53 (p53) to the NDRG1 gene promoter stimulates NDRG1 expression (Stein et al. 2004, Zhang et al. 2007). NDRG1 may positively regulate TP53-mediated apoptosis (Stein et al. 2004) or TP53-mediated cell cycle arrest (Zhang et al. 2007). The exact function of NDRG1 has not been elucidated. Most studies suggest that NDRG1 has a tumor suppressive role, but there are conflicting reports, showing that NDRG1 may act as an oncogene in some settings (reviewed by Liu et al. 2012, Sun and Cao 2013).
Cao, L, Song, Y
Liu, L, Chen, J, Xiao, L, Wang, JY, Zou, T, Turner, DJ, Marasa, BS, Zhang, AH, Rao, JN
Zhao, Q, Sahni, S, Sun, J, Richardson, DR, Yue, F, Zhang, D, Bae, DH, Kovacevic, Z, Zheng, Y, Zheng, M, Jansson, P
Herzog, B, Liang, P, Jackson, RS, Thomas, EK, Wang, M, Westfall, MD, Rocheleau, JV, Stein, S
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