MDM2 binds TP53

Stable Identifier
R-HSA-5633460
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The N-terminal portion of MDM2 binds the N-terminal transactivation domain of TP53 (p53) and inhibits transcriptional transactivation by TP53 (Momand et al. 1992, Oliner et al. 1992, Oliner et al. 1993, Chen et al. 1993).

Participants
Participant Of
This entity is regulated by
Orthologous Events