MDM2 binds TP53

Stable Identifier
R-HSA-5633460
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The N-terminal portion of MDM2 binds the N-terminal transactivation domain of TP53 (p53) and inhibits transcriptional transactivation by TP53 (Momand et al. 1992, Oliner et al. 1992, Oliner et al. 1993, Chen et al. 1993).

Literature References
PubMed ID Title Journal Year
21986495 Regulation of MDM2 E3 ligase activity by phosphorylation after DNA damage

Cheng, Q, Cross, B, Li, B, Chen, L, Li, Z, Chen, J

Mol. Cell. Biol. 2011
1614537 Amplification of a gene encoding a p53-associated protein in human sarcomas

Oliner, JD, Kinzler, KW, Meltzer, PS, George, DL, Vogelstein, B

Nature 1992
14507994 HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53

Linares, LK, Hengstermann, A, Ciechanover, A, Muller, S, Scheffner, M

Proc. Natl. Acad. Sci. U.S.A. 2003
7686617 Mapping of the p53 and mdm-2 interaction domains

Chen, J, Marechal, V, Levine, AJ

Mol. Cell. Biol. 1993
1535557 The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

Momand, J, Zambetti, GP, Olson, DC, George, D, Levine, AJ

Cell 1992
8479525 Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

Oliner, JD, Pietenpol, JA, Thiagalingam, S, Gyuris, J, Kinzler, KW, Vogelstein, B

Nature 1993
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