Positive gene expression regulation by 'atRA:RARA,G:RXRA at active HOXA1 chromatin [nucleoplasm]'

Stable Identifier
R-HSA-5634074
Type
PositiveGeneExpressionRegulation
Locations in the PathwayBrowser
Summation

Regulation of HOXA1 by retinoic acid is inferred from mouse embryos (Frasch et al. 1995, Dupe et al. 1997, Paschaki et al. 2013) and cell lines (Langston and Gudas 1992, Langston et al. 1997, Gillespie and Gudas 2007).

Literature References
PubMed ID Title Journal Year
9053316 In vivo functional analysis of the Hoxa-1 3' retinoic acid response element (3'RARE)

Dupé, V, Davenne, M, Brocard, J, Dollé, P, Mark, M, Dierich, A, Chambon, P, Rijli, FM

Development 1997
17663992 Retinoid regulated association of transcriptional co-regulators and the polycomb group protein SUZ12 with the retinoic acid response elements of Hoxa1, RARbeta(2), and Cyp26A1 in F9 embryonal carcinoma cells

Gillespie, RF, Gudas, LJ

J. Mol. Biol. 2007
1360810 Identification of a retinoic acid responsive enhancer 3' of the murine homeobox gene Hox-1.6

Langston, AW, Gudas, LJ

Mech. Dev. 1992
8999919 Retinoic acid-responsive enhancers located 3' of the Hox A and Hox B homeobox gene clusters. Functional analysis

Langston, AW, Thompson, JR, Gudas, LJ

J. Biol. Chem. 1997
7743939 Evolutionary-conserved enhancers direct region-specific expression of the murine Hoxa-1 and Hoxa-2 loci in both mice and Drosophila

Frasch, M, Chen, X, Lufkin, T

Development 1995
23638021 Transcriptomic analysis of murine embryos lacking endogenous retinoic acid signaling

Paschaki, M, Schneider, C, Rhinn, M, Thibault-Carpentier, C, Dembélé, D, Niederreither, K, Dollé, P

PLoS ONE 2013
Regulation participants
Regulation type
PositiveGeneExpressionRegulation
Regulated entity