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FABP5 dissociates from RXRA:PPARD:atRA
Stable Identifier
R-HSA-5634100
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
Signaling by Retinoic Acid (Homo sapiens)
FABP5 dissociates from RXRA:PPARD:atRA (Homo sapiens)
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In the nucleus, all-trans-retinoic acid (atRA), bounds to epidermal fatty acid-binding protein (FABP5), is transferred to the heterodimeric complex of retinoic acid receptor alpha RXRA) and peroxisome proliferator-activated receptor delta (PPARD). When bound to PPARD, atRA can significantly increase the expression of proteins involved in fatty acid oxidation and energy metabolism via its induction of PPARD (Wolf 2010, Amengual et al. 2012, Noy 2013).
Literature References
PubMed ID
Title
Journal
Year
22871568
Induction of carnitine palmitoyl transferase 1 and fatty acid oxidation by retinoic acid in HepG2 cells
Amengual, J
,
Ribot, J
,
Bonet, ML
,
Petrov, P
,
Palou, A
Int. J. Biochem. Cell Biol.
2012
20042001
Retinoic acid activation of peroxisome proliferation-activated receptor delta represses obesity and insulin resistance
Wolf, G
Nutr. Rev.
2010
23991366
The one-two punch: Retinoic acid suppresses obesity both by promoting energy expenditure and by inhibiting adipogenesis
Noy, N
Adipocyte
2013
Participants
Input
RXRA:PPARD:atRA:FABP5 [nucleoplasm]
(Homo sapiens)
Output
FABP5 [nucleoplasm]
(Homo sapiens)
RXRA:PPARD:atRA [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Signaling by Retinoic Acid (Homo sapiens)
Orthologous Events
FABP5 dissociates from RXRA:PPARD:atRA (Bos taurus)
FABP5 dissociates from RXRA:PPARD:atRA (Caenorhabditis elegans)
FABP5 dissociates from RXRA:PPARD:atRA (Canis familiaris)
FABP5 dissociates from RXRA:PPARD:atRA (Gallus gallus)
FABP5 dissociates from RXRA:PPARD:atRA (Mus musculus)
FABP5 dissociates from RXRA:PPARD:atRA (Rattus norvegicus)
FABP5 dissociates from RXRA:PPARD:atRA (Sus scrofa)
FABP5 dissociates from RXRA:PPARD:atRA (Xenopus tropicalis)
Authored
Jassal, B (2014-05-07)
Reviewed
Duester, G (2014-07-28)
Napoli, JL (2014-09-01)
Created
Jassal, B (2014-11-03)
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