SUMO-CRABP2 dissociates from atRA:RAR:RXR

Stable Identifier
R-HSA-5634103
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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SUMO-CRABP2 dissociates from atRA:RAR:RXR
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In the nucleus, cellular retinoic acid binding protein 2 (CRABP2), bound to all trans retinoic acid (atRA), directly binds to heterodimeric nuclear retinoic acid receptors (RAR:RXR) to form a complex through which atRA is channeled from the binding protein to RAR (Majumdar et al. 2011). The RAR:RXR heterodimer can be formed between any of three receptor isoforms for each; RARA, RARB, or RARG with RXRA, RXRB, or RXRG (Neiderreither and Dolle 2008). RARA requires sumoylation and phosphorylation for ligand binding and nuclear localisation (Zhu et al. 2009, Santos & Kim 2010).

RAR:RXR bind to their RA response elements (RARE, composed of tandem direct repeats of 5'-AGGTCA-3' spaced by either 2 bp or 5 bp (DR2, DR5) in response to their physiological ligand atRA, and regulate gene expression in various biological processes.
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Orthologous Events
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SUMO-CRABP2 dissociates from atRA:RAR:RXR (Drosophila melanogaster)
SUMO-CRABP2 dissociates from atRA:RAR:RXR (Gallus gallus)
SUMO-CRABP2 dissociates from atRA:RAR:RXR (Mus musculus)
SUMO-CRABP2 dissociates from atRA:RAR:RXR (Rattus norvegicus)
SUMO-CRABP2 dissociates from atRA:RAR:RXR (Sus scrofa)
Authored
Jassal, B  (2014-11-03)
Reviewed
Duester, G  (2014-07-28)
Napoli, JL  (2014-09-01)
Created
Jassal, B  (2014-11-03)
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