EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9)

Stable Identifier
R-HSA-5634729
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
EHMT1:EHMT2 (KMT1D:KMT1C) methylates MeK10-histone H3 (H3K9), EHMT1:EHMT2 methylates MeK10-histone H3
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EHMT2 (KMT1C, G9A) and EHMT1 (KMT1D, GLP) are the euchromatic histone H3 lysine-10 (H3K9) mono and di-methyltransferases in mammals (Tachibana et al. 2002, Rice et al. 2003, Tachibana et al. 2005). In vivo they exist predominantly as a heteromeric complex together with WIZ, a multi-zinc finger protein, (Ueda et al. 2006) and are responsible for global H3K9 mono- and di-methylation (Shinkai & Tchibana 2011).

Literature References
PubMed ID Title Journal Year
12130538 G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis

Tachibana, M, Sugimoto, K, Nozaki, M, Ueda, J, Ohta, T, Ohki, M, Fukuda, M, Takeda, N, Niida, H, Kato, H, Shinkai, Y

Genes Dev. 2002
14690610 Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains

Rice, JC, Briggs, SD, Ueberheide, B, Barber, CM, Shabanowitz, J, Hunt, DF, Shinkai, Y, Allis, CD

Mol Cell 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
histone-lysine N-methyltransferase activity of EHMT1:EHMT2 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created