MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9)

Stable Identifier
R-HSA-5634802
Type
Reaction
Species
Homo sapiens
Compartment
cytosol
Synonyms
MECOM, PRDM16 methylate lysine-10 of replicative histone H3
Locations in the PathwayBrowser
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Summation

MECOM (KMT8E, PRDM3) and PRDM16 (KMT8F) are histone 3 lysine-10 (H3K9) methyltransferases responsible for cytoplasmic H3K9 mono-methylation.

Literature References
PubMed ID Title Journal Year
22939622 Prdm3 and Prdm16 are H3K9me1 methyltransferases required for mammalian heterochromatin integrity

Pinheiro, I, Margueron, R, Shukeir, N, Eisold, M, Fritzsch, C, Richter, FM, Mittler, G, Genoud, C, Goyama, S, Kurokawa, M, Son, J, Reinberg, D, Lachner, M, Jenuwein, T

Cell 2012
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
histone-lysine N-methyltransferase activity of PRDM16, MECOM [cytosol]
Physical Entity
PRDM16, MECOM [cytosol]
Activity
histone-lysine N-methyltransferase activity (0018024)
Orthologous Events
MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Bos taurus)
MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Canis familiaris)
MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Mus musculus)
MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Rattus norvegicus)
MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Saccharomyces cerevisiae)
Authored
Jupe, S  (2013-03-12)
Reviewed
Motamedi, M  (2014-11-17)