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CUL3 [nucleoplasm]
Stable Identifier
R-HSA-5635033
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Cullin-3, CUL3_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
GLI2,3 are degraded by the proteasome (Homo sapiens)
SPOP:CUL3:RBX1 [nucleoplasm] (Homo sapiens)
CUL3 [nucleoplasm] (Homo sapiens)
ub-2p-GLI2,3:SPOP:CUL3:RBX1 [nucleoplasm] (Homo sapiens)
SPOP:CUL3:RBX1 [nucleoplasm] (Homo sapiens)
CUL3 [nucleoplasm] (Homo sapiens)
SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Homo sapiens)
2p-GLI:SPOP:CUL3:RBX1 [nucleoplasm] (Homo sapiens)
SPOP:CUL3:RBX1 [nucleoplasm] (Homo sapiens)
CUL3 [nucleoplasm] (Homo sapiens)
ub-2p-GLI2,3:SPOP:CUL3:RBX1 [nucleoplasm] (Homo sapiens)
SPOP:CUL3:RBX1 [nucleoplasm] (Homo sapiens)
CUL3 [nucleoplasm] (Homo sapiens)
phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Homo sapiens)
2p-GLI:SPOP:CUL3:RBX1 [nucleoplasm] (Homo sapiens)
SPOP:CUL3:RBX1 [nucleoplasm] (Homo sapiens)
CUL3 [nucleoplasm] (Homo sapiens)
SPOP:CUL3:RBX1 [nucleoplasm] (Homo sapiens)
CUL3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13618 CUL3
Gene Names
CUL3, KIAA0617
Chain
initiator methionine:1, chain:2-768
Reference Genes
BioGPS Gene:8452 CUL3
COSMIC (genes):CUL3 CUL3
CTD Gene:8452 CUL3
dbSNP Gene:8452 CUL3
ENSEMBL:ENSG00000036257 CUL3
HGNC:2553 CUL3
KEGG Gene (Homo sapiens):8452 CUL3
Monarch:8452 CUL3
NCBI Gene:8452 CUL3
OMIM:603136 CUL3
UCSC:Q13618 CUL3
Reference Transcript
RefSeq:NM_001257197.1 CUL3
RefSeq:NM_003590.4 CUL3
RefSeq:NM_001257198.1 CUL3
Other Identifiers
0002470711
0002680050
11716505_a_at
11716506_s_at
11716507_at
11716508_at
16909049
201370_s_at
201371_s_at
201372_s_at
2601552
2601553
2601554
2601555
2601556
2601557
2601560
2601562
2601570
2601571
2601573
2601577
2601579
2601581
2601582
2601584
2601585
2601587
2601589
2601601
2601607
2601610
2601615
2601616
37702_at
8059393
8452
A_23_P209288
A_24_P140030
A_33_P3321150
GE53336
GO:0000082
GO:0000122
GO:0000139
GO:0000165
GO:0000209
GO:0000278
GO:0000902
GO:0000922
GO:0001701
GO:0001831
GO:0003674
GO:0004842
GO:0005112
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005794
GO:0005813
GO:0005815
GO:0005819
GO:0005827
GO:0005829
GO:0005856
GO:0005929
GO:0006357
GO:0006464
GO:0006511
GO:0006513
GO:0006810
GO:0006888
GO:0006950
GO:0007010
GO:0007049
GO:0007059
GO:0007080
GO:0007165
GO:0007229
GO:0007267
GO:0007369
GO:0008150
GO:0008219
GO:0008283
GO:0008284
GO:0009056
GO:0009058
GO:0009790
GO:0016020
GO:0016055
GO:0016192
GO:0016477
GO:0016567
GO:0017145
GO:0019899
GO:0022607
GO:0030030
GO:0030154
GO:0030332
GO:0031145
GO:0031208
GO:0031398
GO:0031461
GO:0031463
GO:0031514
GO:0031625
GO:0031648
GO:0032467
GO:0032991
GO:0034641
GO:0035024
GO:0036126
GO:0040011
GO:0040016
GO:0042995
GO:0043149
GO:0043161
GO:0043226
GO:0043687
GO:0044346
GO:0045842
GO:0048208
GO:0048646
GO:0048856
GO:0048870
GO:0051276
GO:0051301
GO:0051865
GO:0061024
GO:0061630
GO:0065003
GO:0070062
GO:0071630
GO:0072576
GO:0072686
GO:0090090
GO:0097193
GO:0140014
GO:1901992
Hs.78946.0.A2_3p_a_at
ILMN_1653670
PH_hs_0004555
TC02002826.hg
U58089_at
g3139078_3p_a_at
g4503164_3p_a_at
Participant Of
hasComponent
SPOP:CUL3:RBX1 [nucleoplasm]
Other forms of this molecule
G76-NEDD8-K712-CUL3 [cytosol]
CUL3 [cytosol]
Inferred To
Ghost homologue of CUL3 [nucleoplasm] (Bos taurus)
cul3b [nucleoplasm] (Danio rerio)
CUL3 [nucleoplasm] (Canis familiaris)
CUL3 [nucleoplasm] (Gallus gallus)
CUL3 [nucleoplasm] (Sus scrofa)
culC [nucleoplasm] (Dictyostelium discoideum)
Cul3 [nucleoplasm] (Drosophila melanogaster)
Cul3 [nucleoplasm] (Mus musculus)
Cul3 [nucleoplasm] (Rattus norvegicus)
cul-3 [nucleoplasm] (Caenorhabditis elegans)
cul3 [nucleoplasm] (Xenopus tropicalis)
Cross References
RefSeq
NP_003581.1
,
NP_001244126.1
,
NP_001244127.1
OpenTargets
ENSG00000036257
GeneCards
Q13618
HPA
ENSG00000036257-CUL3
Ensembl
ENST00000344951
,
ENSP00000343601
,
ENST00000409777
,
ENSP00000387200
,
ENSG00000036257
,
ENST00000264414
,
ENSP00000264414
,
ENST00000409096
,
ENSP00000386525
PRO
Q13618
Orphanet
21177
PDB
2MYM
,
4EOZ
,
5NLB
,
6I2M
,
4AP2
,
2MYL
,
4HXI
,
4APF
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8NC69 KCTD6
1
KCTD6 [cytosol]
(R-HSA-8863321)
0.83
11
UniProt:P08238 HSP90AB1
6
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.641
3
UniProt:O94888 UBXN7
1
UBXN7 [cytosol]
(R-HSA-8956071)
0.623
6
UniProt:Q86VP6 CAND1
5
CAND1 [ficolin-1-rich granule lumen]
(R-HSA-6801399)
CAND1 [nucleoplasm]
(R-HSA-8955089)
CAND1 [extracellular region]
(R-HSA-6806498)
CAND1 [secretory granule lumen]
(R-HSA-6801390)
CAND1 [cytosol]
(R-HSA-5691146)
0.623
6
UniProt:Q14790 CASP8
8
CASP8(1-216) [cytosol]
(R-HSA-933456)
CASP8(375-384) [cytosol]
(R-HSA-933460)
CASP8(1-374) [cytosol]
(R-HSA-3465404)
CASP8(217-374) [mitochondrial outer membrane]
(R-HSA-351869)
CASP8(385-479) [mitochondrial outer membrane]
(R-HSA-351828)
CASP8(1-479) [cytosol]
(R-HSA-57031)
CASP8(385-479) [cytosol]
(R-HSA-76158)
CASP8(217-374) [cytosol]
(R-HSA-75975)
0.602
6
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
3
UniProt:Q15369 ELOC
2
TCEB1 [nucleoplasm]
(R-HSA-112422)
ELOC [cytosol]
(R-HSA-180535)
0.547
3
UniProt:Q8IY81 FTSJ3
1
FTSJ3 [nucleoplasm]
(R-HSA-6791507)
0.527
2
UniProt:Q15084 PDIA6
3
p-PDIA6 [endoplasmic reticulum lumen]
(R-HSA-8957031)
PDIA6 [endoplasmic reticulum membrane]
(R-HSA-535530)
PDIA6 [endoplasmic reticulum lumen]
(R-HSA-3009049)
0.527
2
UniProt:Q15843 NEDD8
17
C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm]
(R-HSA-8952504)
K1881-CUL9-G76-NEDD8 [cytosol]
(R-HSA-8955924)
NEDD8 [nucleoplasm]
(R-HSA-8955926)
K705-CUL4A-G76-NEDD8 [nucleoplasm]
(R-HSA-8952528)
K859-CUL4B-G76-NEDD8 [nucleoplasm]
(R-HSA-8952538)
NEDD8(77-88) [cytosol]
(R-HSA-6782654)
NEDD8(1-88) [cytosol]
(R-HSA-5690794)
C237-UBA3-G76-NEDD8 [cytosol]
(R-HSA-8951647)
C116-AcM-UBE2F-G76-NEDD8 [cytosol]
(R-HSA-8951739)
K720-CUL1-G76-NEDD8 [cytosol]
(R-HSA-8952534)
K712-CUL3-G76-NEDD8 [cytosol]
(R-HSA-8952531)
K689-CUL2-G76-NEDD8 [cytosol]
(R-HSA-8952526)
K724-CUL5-G76-NEDD8 [cytosol]
(R-HSA-8952018)
NEDD8 [cytosol]
(R-HSA-416969)
K567-TGFBR2-G76-NEDD8 [cytosol]
(R-HSA-4419906)
K556-TGFBR2-G76-NEDD8 [cytosol]
(R-HSA-4419907)
C111-AcM-UBE2M-G76-NEDD8 [cytosol]
(R-HSA-4419895)
0.527
7
UniProt:P55265 ADAR
1
ADAR [nucleoplasm]
(R-HSA-53939)
0.527
2
UniProt:O75489 NDUFS3
1
NDUFS3 [mitochondrial matrix]
(R-HSA-163927)
0.527
2
UniProt:P78527 PRKDC
4
PRKDC [nucleoplasm]
(R-HSA-62161)
p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm]
(R-HSA-76302)
PRKDC [cytosol]
(R-HSA-3134816)
K48polyUb-PRKDC [cytosol]
(R-HSA-8938766)
0.527
2
UniProt:Q8IWE4 DCUN1D3
2
DCUN1D3 [cytosol]
(R-HSA-8951782)
MyrG-DCUN1D3 [plasma membrane]
(R-HSA-8956204)
0.499
2
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