Reactome | CUL3 [nucleoplasm]

CUL3 [nucleoplasm]

Stable Identifier

R-HSA-5635033

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Cullin-3, CUL3_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q13618 CUL3

Gene Names

CUL3, KIAA0617

Chain

initiator methionine:1, chain:2-768

Reference Genes

BioGPS Gene:8452 CUL3

COSMIC (genes):CUL3 CUL3

CTD Gene:8452 CUL3

dbSNP Gene:8452 CUL3

ENSEMBL:ENSG00000036257 CUL3

HGNC:2553 CUL3

KEGG:hsa:8452 CUL3

Monarch:8452 CUL3

NCBI Gene:8452 CUL3

OMIM:603136 CUL3

UCSC:Q13618 CUL3

Reference Transcript

Participates

as a component of

SPOP:CUL3:RBX1 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

CUL3 [cytosol]

G76-NEDD8-K712-CUL3 [cytosol]

Inferred To

Ghost homologue of CUL3 [nucleoplasm] (Canis familiaris)

Ghost homologue of CUL3 [nucleoplasm] (Sus scrofa)

cul3b [nucleoplasm] (Danio rerio)

CUL3 [nucleoplasm] (Bos taurus)

CUL3 [nucleoplasm] (Gallus gallus)

culC [nucleoplasm] (Dictyostelium discoideum)

Cul3 [nucleoplasm] (Drosophila melanogaster)

Cul3 [nucleoplasm] (Mus musculus)

Cul3 [nucleoplasm] (Rattus norvegicus)

cul-3 [nucleoplasm] (Caenorhabditis elegans)

cul3 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001244127.1, NP_001244126.1, NP_003581.1

OpenTargets

ENSG00000036257

ENSEMBL

ENSP00000264414, ENSP00000386525, ENST00000344951, ENSG00000036257, ENST00000264414, ENSP00000343601, ENST00000409096, ENSP00000387200, ENST00000409777

GeneCards

CUL3

HPA

ENSG00000036257-CUL3

PRO

Q13618

Pharos - Targets

Q13618

GlyGen

Q13618

Orphanet

CUL3

HMDB Protein

HMDBP12790

PDB

4APF, 4HXI, 2MYL, 2MYM, 8H3Q, 8H37, 6I2M, 5NLB, 4AP2, 4EOZ, 8H3A, 8H3F, 8U83, 8U81, 8K9I, 8H38, 8H35, 8H34, 8I79, 8K8T, 8H33, 8H36, 8KHP, 8U84, 8U82, 8U80, 8H3R, 8GQ6

Interactors (35)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43791 SPOP	3	SPOP [cytosol] (R-HSA-9929375) p-S6-SPOP [cytosol] (R-HSA-9929374) SPOP [nucleoplasm] (R-HSA-5635035)	0.89	13
UniProt:Q8NC69 KCTD6	1	KCTD6 [cytosol] (R-HSA-8863321)	0.871	13
UniProt:Q92905 COPS5	3	CSN5 [cytosol] (R-HSA-9929354) COPS5 [nucleoplasm] (R-HSA-5697019) COPS5 [cytosol] (R-HSA-416963)	0.823	13
UniProt:P62877 RBX1	2	RBX1 [nucleoplasm] (R-HSA-1234142) RBX1 [cytosol] (R-HSA-180582)	0.819	7
UniProt:Q86VP6 CAND1	5	CAND1 [cytosol] (R-HSA-5691146) CAND1 [secretory granule lumen] (R-HSA-6801390) CAND1 [extracellular region] (R-HSA-6806498) CAND1 [ficolin-1-rich granule lumen] (R-HSA-6801399) CAND1 [nucleoplasm] (R-HSA-8955089)	0.748	8
UniProt:O94955 RHOBTB3	1	RHOBTB3 [trans-Golgi network membrane] (R-HSA-6813908)	0.725	5
UniProt:Q15843 NEDD8	8	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) NEDD8 [nucleoplasm] (R-HSA-8955926) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895) NEDD8 [cytosol] (R-HSA-416969) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) NEDD8(1-81) [cytosol] (R-HSA-5690794) NEDD8(77-81) [cytosol] (R-HSA-6782654) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739)	0.725	9
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491)	0.723	4
UniProt:Q14145 KEAP1	3	KEAP1 [cytosol] (R-HSA-976038) ub-KEAP1 [cytosol] (R-HSA-9766647) Ub-KEAP1 [cytosol] (R-HSA-6782766)	0.666	5
UniProt:O94888 UBXN7	2	UBXN7 [cytosol] (R-HSA-8956071) ub-UBXN7 [cytosol] (R-HSA-9755305)	0.623	6
UniProt:Q14790 CASP8	8	CASP8(1-479) [cytosol] (R-HSA-57031) CASP8(1-216) [cytosol] (R-HSA-933456) CASP8(217-374) [cytosol] (R-HSA-75975) CASP8(375-384) [cytosol] (R-HSA-933460) CASP8(385-479) [cytosol] (R-HSA-76158) CASP8(385-479) [mitochondrial outer membrane] (R-HSA-351828) CASP8(217-374) [mitochondrial outer membrane] (R-HSA-351869) CASP8(1-374) [cytosol] (R-HSA-3465404)	0.602	6
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:Q15369 ELOC	2	ELOC [cytosol] (R-HSA-180535) TCEB1 [nucleoplasm] (R-HSA-112422)	0.547	3
UniProt:O75489 NDUFS3	2	NDUFS3 [mitochondrial matrix] (R-HSA-163927) NDUFS3 [cytosol] (R-HSA-9714751)	0.527	2
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) CTNNB1 [nucleoplasm] (R-HSA-3451168) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1(116-376) [cytosol] (R-HSA-202950) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) p-Y-CTNNB1 [cytosol] (R-HSA-8876940) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926)	0.527	2
UniProt:O43143 DHX15	1	DHX15 [nucleoplasm] (R-HSA-5688097)	0.527	2
UniProt:Q8IY81 FTSJ3	1	FTSJ3 [nucleoplasm] (R-HSA-6791507)	0.527	2
UniProt:O94844 RHOBTB1	1	RHOBTB1 [endosome membrane] (R-HSA-194899)	0.527	5
UniProt:Q96GD4 AURKB	3	AURKB [cytosol] (R-HSA-174231) AURKB [nucleoplasm] (R-HSA-4655360) polySUMO2,3-K202-AURKB [cytosol] (R-HSA-4655414)	0.527	2
UniProt:Q9ULX6 AKAP8L	1	AKAP8L [nucleoplasm] (R-HSA-9821364)	0.527	2
UniProt:Q9BYZ6 RHOBTB2	1	RHOBTB2 [endosome membrane] (R-HSA-194907)	0.527	2
UniProt:P22314 UBA1	2	UBA1 [cytosol] (R-HSA-947698) UBA1 [nucleoplasm] (R-HSA-8852116)	0.527	2
UniProt:Q9Y4X5 ARIH1	1	ARIH1 [cytosol] (R-HSA-1678825)	0.527	2
UniProt:P07900 HSP90AA1	8	HSP90AA1 [lysosomal lumen] (R-HSA-9622850) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470)	0.527	2
UniProt:P78527 PRKDC	4	PRKDC [nucleoplasm] (R-HSA-62161) p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm] (R-HSA-76302) PRKDC [cytosol] (R-HSA-3134816) K48polyUb-PRKDC [cytosol] (R-HSA-8938766)	0.527	2
UniProt:P07737 PFN1	2	PFN1 [cytosol] (R-HSA-203081) PFN1 [extracellular region] (R-HSA-350755)	0.527	2
UniProt:Q15084 PDIA6	3	PDIA6 [endoplasmic reticulum lumen] (R-HSA-3009049) p-PDIA6 [endoplasmic reticulum lumen] (R-HSA-8957031) PDIA6 [endoplasmic reticulum membrane] (R-HSA-535530)	0.527	2
UniProt:P06733 ENO1	1	ENO1 [cytosol] (R-HSA-71437)	0.527	2
UniProt:P62191 PSMC1	2	PSMC1 [cytosol] (R-HSA-68768) PSMC1 [nucleoplasm] (R-HSA-174338)	0.527	2
UniProt:P62937 PPIA	5	PPIA [extracellular region] (R-HSA-173646) PPIA [secretory granule lumen] (R-HSA-6801400) PPIA [ficolin-1-rich granule lumen] (R-HSA-6801391) PPIA [cytosol] (R-HSA-173123) PPIA [extracellular exosome] (R-HSA-6801538)	0.527	2
UniProt:P07437 TUBB	3	TUBB [extracellular region] (R-HSA-380317) TUBB [azurophil granule lumen] (R-HSA-6799370) TUBB [cytosol] (R-HSA-9020816)	0.527	2
UniProt:Q13427 PPIG	2	PPIG [nucleoplasm] (R-HSA-9769592) PPIG [cytosol] (R-HSA-9728768)	0.527	2
UniProt:Q9UF56 FBXL17	1	FBXL17 [nucleoplasm] (R-HSA-9708570)	0.527	4
UniProt:P55265 ADAR	2	ADAR [nucleoplasm] (R-HSA-53939) ADAR1 [cytosol] (R-HSA-9835955)	0.527	2
UniProt:Q8IWE4 DCUN1D3	2	MyrG-DCUN1D3 [plasma membrane] (R-HSA-8956204) DCUN1D3 [cytosol] (R-HSA-8951782)	0.499	2

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