Reactome | SPOP [nucleoplasm]

SPOP [nucleoplasm]

Stable Identifier

R-HSA-5635035

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

Expand all

Literature References

PubMed ID	Title	Journal	Year
26344095	SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression Gan, W, Dai, X, Lunardi, A, Li, Z, Inuzuka, H, Liu, P, Varmeh, S, Zhang, J, Cheng, L, Sun, Y, Asara, JM, Beck, AH, Huang, J, Pandolfi, PP, Wei, W	Mol. Cell	2015

External Reference Information

External Reference

UniProt:O43791 SPOP

Gene Names

SPOP

Chain

chain:1-374

Reference Genes

BioGPS Gene:8405 SPOP

COSMIC (genes):SPOP SPOP

CTD Gene:8405 SPOP

dbSNP Gene:8405 SPOP

ENSEMBL:ENSG00000121067 SPOP

HGNC:11254 SPOP

KEGG Gene (Homo sapiens):8405 SPOP

Monarch:8405 SPOP

NCBI Gene:8405 SPOP

OMIM:602650 SPOP

UCSC:O43791 SPOP

Reference Transcript

Other Identifiers

0002470278

11730177_a_at

11730178_s_at

11730179_a_at

11743913_s_at

16846448

204640_s_at

208927_at

238923_at

2CR2

3761902

3761904

3761906

3761907

3761908

3761909

3761912

3761917

3761919

3761923

3761926

3761927

3761928

3761930

3761931

3761936

3761938

3761947

3761948

39423_f_at

3HQH

3HQI

3HQL

3HQM

3HSV

3HTM

3HU6

3IVB

3IVQ

3IVV

44052_at

4EOZ

4HS2

4J8Z

4O1V

6F8F

6F8G

8016562

80786_at

8405

A_23_P107257

A_24_P270890

AAH01269

AAH03385

AJ000644

AK222589

AK312691

BAD96309

BAG35570

BC001269

BC003385

CAA04199

CCDS11551

CH471109

D6RA79

D6RBR3

D6RD94

D6RDG8

D6RFL7

D6RGZ4

D6RIS7

EAW94671

EAW94672

EAW94673

EAW94674

EAW94675

ENSG00000121067

ENSP00000240327

ENSP00000377001

ENSP00000420908

ENSP00000425905

ENST00000347630

ENST00000347630.6

ENST00000393328

ENST00000393328.6

ENST00000503676

ENST00000503676.5

ENST00000504102

EntrezGene:8405

EntrezGene:SPOP

g4507182_3p_a_at

GE55133

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005737

GO:0006464

GO:0006511

GO:0008150

GO:0009056

GO:0016567

GO:0016607

GO:0019899

GO:0030162

GO:0031463

GO:0031625

GO:0032991

GO:0043161

GO:0043226

HGNC:11254

Hs.129951.1.S2_3p_at

Hs.151316.0.A1_3p_at

ILMN_1795404

ILMN_2397024

IPR000210

IPR002083

IPR008974

IPR011333

MIM:602650

NM_001007226

NM_001007227

NM_001007228

NM_001007229

NM_001370730

NM_001370731

NM_001370732

NM_003563

NP_001007227

NP_001007228

NP_001007229

NP_001007230

NP_001357659

NP_001357660

NP_001357661

NP_003554

PF00651

PF00917

PH_hs_0007623

SM00061

SM00225

SPOP

SPOP-201

SPOP-202

SPOP-205

SPOP-206

TC17001670.hg

UPI0000003F5C

XM_024450995

XP_005257780

XP_005257781

XP_016880693

XP_024306763

Participant Of

hasComponent

Inferred To

bath-41 [nucleoplasm] (Caenorhabditis elegans)

Spop [nucleoplasm] (Mus musculus)

Spop [nucleoplasm] (Rattus norvegicus)

bath-44 [nucleoplasm] (Caenorhabditis elegans)

mel-26 [nucleoplasm] (Caenorhabditis elegans)

bath-40 [nucleoplasm] (Caenorhabditis elegans)

rdx [nucleoplasm] (Drosophila melanogaster)

Homologues of SPOP [nucleoplasm] (Caenorhabditis elegans)

Homologues of SPOP [nucleoplasm] (Dictyostelium discoideum)

Homologues of SPOP [nucleoplasm] (Drosophila melanogaster)

spop [nucleoplasm] (Danio rerio)

spop [nucleoplasm] (Xenopus tropicalis)

Dmel\CG11275 [nucleoplasm] (Drosophila melanogaster)

SPOP [nucleoplasm] (Bos taurus)

SPOP [nucleoplasm] (Canis familiaris)

SPOP [nucleoplasm] (Dictyostelium discoideum)

SPOP [nucleoplasm] (Gallus gallus)

SPOP [nucleoplasm] (Sus scrofa)

bath-43 [nucleoplasm] (Caenorhabditis elegans)

bath-42 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

XP_005257781.1, NP_001007231.1, NP_001007227.1, XP_016880693.1, NP_001007228.1, NP_003554.1, NP_001007229.1, XP_005257780.1, NP_001007230.1

OpenTargets

ENSG00000121067

HPA

ENSG00000121067-SPOP

GeneCards

O43791

Ensembl

ENSP00000377001, ENST00000504102, ENSP00000240327, ENSG00000121067, ENST00000393328, ENST00000503676, ENST00000347630, ENSP00000420908, ENSP00000425905

PRO

O43791

PDB

2CR2, 3HQM, 3HQH, 3IVQ, 3HQI, 3IVB, 4J8Z, 3HTM, 6I68, 3HSV, 3IVV, 4O1V, 6I41, 4HS2, 6F8F, 3HQL, 6I5P, 6F8G, 4EOZ, 3HU6, 6I7A

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q99836 MYD88	9	MyD88 E52del [cytosol] (R-HSA-5602451) MyD88 R196C [cytosol] (R-HSA-5602329) MyD88 L93P [cytosol] (R-HSA-5602612) MyD88 S34Y [cytosol] (R-HSA-5602521) MyD88 E65del [cytosol] (R-HSA-5602598) MYD88 [cytosol] (R-HSA-193946) MYD88 [plasma membrane] (R-HSA-937017) MYD88 [cytosol] (R-HSA-166059) MYD88 [endosome membrane] (R-HSA-975123)	0.786	7
UniProt:Q9UER7 DAXX	2	DAXX [nucleoplasm] (R-HSA-3222068) SUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086)	0.69	5
UniProt:Q9Y6Q9 NCOA3	2	p-S857 NCOA3 [nucleoplasm] (R-HSA-5687005) NCOA3 [nucleoplasm] (R-HSA-442488)	0.632	6
UniProt:P60484 PTEN	122	PTEN [nucleoplasm] (R-HSA-5690148) K48polyUb-PTEN [cytosol] (R-HSA-8874327) PolyUb-PTEN [nucleoplasm] (R-HSA-6782515) PTEN H93R [cytosol] (R-HSA-2318524) PTEN C124R [cytosol] (R-HSA-2317439) PTEN H93Y [cytosol] (R-HSA-2318520) PTEN R130G [cytosol] (R-HSA-2317339) PTEN H93D [cytosol] (R-HSA-2318550) PTEN R130L [cytosol] (R-HSA-2317430) PTEN H93A [cytosol] (R-HSA-2318544) PTEN G129E [cytosol] (R-HSA-2318509) PTEN S170N [cytosol] (R-HSA-2318408) PTEN R173P [cytosol] (R-HSA-2317480) PTEN R130Q [cytosol] (R-HSA-2317416) PTEN H93Q [cytosol] (R-HSA-2318565) PTEN G129R [cytosol] (R-HSA-2318501) PTEN H123Y [cytosol] (R-HSA-2318469) PTEN S170R [cytosol] (R-HSA-2318437) PTEN R173C [cytosol] (R-HSA-2317478) PTEN R173H [cytosol] (R-HSA-2317473) PTEN C124S [cytosol] (R-HSA-2317379) PTEN C124Y [cytosol] (R-HSA-2317464) PTEN R130P [cytosol] (R-HSA-2317432) PTEN C124F [cytosol] (R-HSA-2317461) PTEN G129V [cytosol] (R-HSA-2318503) PTEN S170I [cytosol] (R-HSA-2318455) PTEN S170G [cytosol] (R-HSA-2318465) PTEN E99* [cytosol] (R-HSA-9659052) PTEN G165* [cytosol] (R-HSA-9659117) PTEN E157* [cytosol] (R-HSA-9658926) PTEN E150* [cytosol] (R-HSA-9658920) PTEN E43* [cytosol] (R-HSA-9659049) PTEN Q17* [cytosol] (R-HSA-9659305) PTEN E91* [cytosol] (R-HSA-9659050) PTEN S59* [cytosol] (R-HSA-9659360) PTEN E114* [cytosol] (R-HSA-9658915) PTEN L139* [cytosol] (R-HSA-9659196) PTEN Y176* [cytosol] (R-HSA-9659389) PTEN Y177* [cytosol] (R-HSA-9659390) PTEN Q149* [cytosol] (R-HSA-9659320) PTEN L146* [cytosol] (R-HSA-9659193) PTEN G20* [cytosol] (R-HSA-9659129) PTEN G127* [cytosol] (R-HSA-9659130) PTEN Y46* [cytosol] (R-HSA-9659387) PTEN L182* [cytosol] (R-HSA-9659189) PTEN Q97* [cytosol] (R-HSA-9659318) PTEN Q171* [cytosol] (R-HSA-9659312) PTEN G129* [cytosol] (R-HSA-9659120) PTEN E18* [cytosol] (R-HSA-9658931) PTEN Y180* [cytosol] (R-HSA-9659404) PTEN K163* [cytosol] (R-HSA-9659148) PTEN Y27* [cytosol] (R-HSA-9659405) PTEN Y65* [cytosol] (R-HSA-9659406) PTEN Y68* [cytosol] (R-HSA-9659400) PTEN K128* [cytosol] (R-HSA-9659145) PTEN Y138* [cytosol] (R-HSA-9659402) PTEN K125* [cytosol] (R-HSA-9659147) PTEN Y88* [cytosol] (R-HSA-9659399) PTEN Q110* [cytosol] (R-HSA-9659328) PTEN L23* [cytosol] (R-HSA-9659201) PTEN E7* [cytosol] (R-HSA-9659036) PTEN C105* [cytosol] (R-HSA-9658911) PTEN E73* [cytosol] (R-HSA-9659039) PTEN K62* [cytosol] (R-HSA-9659160) PTEN E40* [cytosol] (R-HSA-9659032) PTEN Y178* [cytosol] (R-HSA-9659417) PTEN R130* [cytosol] (R-HSA-2318571) PTEN W111* [cytosol] (R-HSA-9659414) PTEN R11* [cytosol] (R-HSA-9659350) PTEN K13* [cytosol] (R-HSA-9659152) PTEN Y174* [cytosol] (R-HSA-9659409) PTEN K147* [cytosol] (R-HSA-9659153) PTEN R84* [cytosol] (R-HSA-9659347) PTEN G293* [cytosol] (R-HSA-9659113) PTEN S287* [cytosol] (R-HSA-9659371) PTEN Q214* [cytosol] (R-HSA-9659307) PTEN S229* [cytosol] (R-HSA-9659366) PTEN Q219* [cytosol] (R-HSA-9659302) PTEN Q261* [cytosol] (R-HSA-9659303) PTEN E299* [cytosol] (R-HSA-9659040) PTEN Y336* [cytosol] (R-HSA-9659388) PTEN Q245* [cytosol] (R-HSA-9659326) PTEN Y225* [cytosol] (R-HSA-9659391) PTEN Y240* [cytosol] (R-HSA-9659385) PTEN C218* [cytosol] (R-HSA-9659065) PTEN C250* [cytosol] (R-HSA-9659066) PTEN L247* [cytosol] (R-HSA-9659195) PTEN G209* [cytosol] (R-HSA-9659124) PTEN C211* [cytosol] (R-HSA-9659062) PTEN G230* [cytosol] (R-HSA-9659121) PTEN Q298* [cytosol] (R-HSA-9659314) PTEN L320* [cytosol] (R-HSA-9659187) PTEN E242* [cytosol] (R-HSA-9659084) PTEN K332* [cytosol] (R-HSA-9659151) PTEN E284* [cytosol] (R-HSA-9659087) PTEN E291* [cytosol] (R-HSA-9659081) PTEN K330* [cytosol] (R-HSA-9659146) PTEN E314* [cytosol] (R-HSA-9659078) PTEN Y346* [cytosol] (R-HSA-9659392) PTEN C296* [cytosol] (R-HSA-9659072) PTEN W274* [cytosol] (R-HSA-9659393) PTEN R233* [cytosol] (R-HSA-2318573) PTEN R335* [cytosol] (R-HSA-2318568) PTEN E256* [cytosol] (R-HSA-9659098) PTEN R189* [cytosol] (R-HSA-9659354) PTEN E307* [cytosol] (R-HSA-9659099) PTEN K263* [cytosol] (R-HSA-9659156) PTEN E235* [cytosol] (R-HSA-9659029) PTEN E288* [cytosol] (R-HSA-9659094) PTEN K221* [cytosol] (R-HSA-9659158) PTEN K344* [cytosol] (R-HSA-9659159) MonoUb-K13,K289-PTEN [cytosol] (R-HSA-6807247) PTEN [nucleoplasm] (R-HSA-6807273) MonoUb-K13,K289-PTEN [nucleoplasm] (R-HSA-6807264) PolyUb-K324,K344,K349-RibC-E40,E150,D326-PTEN [cytosol] (R-HSA-8948841) p-Y336-PTEN [cytosol] (R-HSA-8847980) p-3S,2T-PTEN [cytosol] (R-HSA-8850936) PTEN [cytosol] (R-HSA-199420) K27polyUb-PTEN [cytosol] (R-HSA-8851009) K48polyUb-K289-PTEN [cytosol] (R-HSA-8948777) RibC-E40,E150,D326-PTEN [cytosol] (R-HSA-8948798) PolyUb-PTEN [cytosol] (R-HSA-6807280)	0.611	4