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SPOPL [nucleoplasm]
Stable Identifier
R-HSA-5635036
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
GLI2,3 are degraded by the proteasome (Homo sapiens)
SPOP:CUL3:RBX1 [nucleoplasm] (Homo sapiens)
SPOP dimer [nucleoplasm] (Homo sapiens)
SPOP:SPOPL [nucleoplasm] (Homo sapiens)
SPOPL [nucleoplasm] (Homo sapiens)
ub-2p-GLI2,3:SPOP:CUL3:RBX1 [nucleoplasm] (Homo sapiens)
SPOP:CUL3:RBX1 [nucleoplasm] (Homo sapiens)
SPOP dimer [nucleoplasm] (Homo sapiens)
SPOP:SPOPL [nucleoplasm] (Homo sapiens)
SPOPL [nucleoplasm] (Homo sapiens)
SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Homo sapiens)
2p-GLI:SPOP:CUL3:RBX1 [nucleoplasm] (Homo sapiens)
SPOP:CUL3:RBX1 [nucleoplasm] (Homo sapiens)
SPOP dimer [nucleoplasm] (Homo sapiens)
SPOP:SPOPL [nucleoplasm] (Homo sapiens)
SPOPL [nucleoplasm] (Homo sapiens)
ub-2p-GLI2,3:SPOP:CUL3:RBX1 [nucleoplasm] (Homo sapiens)
SPOP:CUL3:RBX1 [nucleoplasm] (Homo sapiens)
SPOP dimer [nucleoplasm] (Homo sapiens)
SPOP:SPOPL [nucleoplasm] (Homo sapiens)
SPOPL [nucleoplasm] (Homo sapiens)
phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Homo sapiens)
2p-GLI:SPOP:CUL3:RBX1 [nucleoplasm] (Homo sapiens)
SPOP:CUL3:RBX1 [nucleoplasm] (Homo sapiens)
SPOP dimer [nucleoplasm] (Homo sapiens)
SPOP:SPOPL [nucleoplasm] (Homo sapiens)
SPOPL [nucleoplasm] (Homo sapiens)
SPOP:CUL3:RBX1 [nucleoplasm] (Homo sapiens)
SPOP dimer [nucleoplasm] (Homo sapiens)
SPOP:SPOPL [nucleoplasm] (Homo sapiens)
SPOPL [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q6IQ16 SPOPL
Gene Names
SPOPL
Chain
chain:1-392
Reference Genes
BioGPS Gene:339745 SPOPL
COSMIC (genes):SPOPL SPOPL
CTD Gene:339745 SPOPL
dbSNP Gene:339745 SPOPL
ENSEMBL:ENSG00000144228 SPOPL
ENSEMBL:ENSG00000144228.9 SPOPL
HGNC:27934 SPOPL
KEGG Gene (Homo sapiens):339745 SPOPL
Monarch:339745 SPOPL
NCBI Gene:339745 SPOPL
UCSC:Q6IQ16 SPOPL
Reference Transcript
RefSeq:NM_001001664.2 SPOPL
Other Identifiers
11724643_at
11724644_at
11724645_at
11758137_s_at
16886130
225658_PM_at
225658_at
225659_PM_at
225659_at
243170_PM_at
243170_at
2508017
2508027
2508028
2508030
2508031
2508032
2508033
2508034
2508036
2508040
2508042
2508045
2508049
2508050
2508054
2508055
2508056
2508057
2508058
2508059
2508061
2772228
339745
43054_r_at
52421_at
58783_at
67402_at
8045514
91171_at
A_23_P79681
A_24_P551028
GO:0005515
GO:0005634
GO:0005737
GO:0016567
GO:0030162
GO:0030163
GO:0031397
GO:0031463
GO:0031625
GO:0036211
GO:0043161
GO:0043226
HMNXSV003007253
HMNXSV003043622
Hs.125790.1.A1_3p_at
Hs.125790.1.A2_3p_at
Hs.185018.0.A1_3p_at
ILMN_1807649
ILMN_2095506
PH_hs_0032058
TC02000894.hg
p10033
Participates
as a component of
SPOP:SPOPL [nucleoplasm] (Homo sapiens)
Inferred To
spopla [nucleoplasm]
(Danio rerio)
rdx [nucleoplasm]
(Drosophila melanogaster)
spopl [nucleoplasm]
(Xenopus tropicalis)
spop-1 [nucleoplasm]
(Caenorhabditis elegans)
Spopl [nucleoplasm]
(Mus musculus)
Spopl [nucleoplasm]
(Rattus norvegicus)
SPOPL [nucleoplasm]
(Bos taurus)
SPOPL [nucleoplasm]
(Canis familiaris)
SPOPL [nucleoplasm]
(Gallus gallus)
SPOPL [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_001001664.1
OpenTargets
ENSG00000144228
GeneCards
Q6IQ16
HPA
ENSG00000144228-SPOPL
Ensembl
ENSG00000144228
,
ENSP00000280098
,
ENST00000280098
PRO
Q6IQ16
Pharos - Targets
Q6IQ16
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P15336 ATF2
2
ATF2 [nucleoplasm]
(R-HSA-450336)
p-T69,T71-ATF2 [nucleoplasm]
(R-HSA-450243)
0.556
3
UniProt:Q99836 MYD88
8
MyD88 R196C [cytosol]
(R-HSA-5602329)
MyD88 E52del [cytosol]
(R-HSA-5602451)
MyD88 L93P [cytosol]
(R-HSA-5602612)
MyD88 S34Y [cytosol]
(R-HSA-5602521)
MyD88 E65del [cytosol]
(R-HSA-5602598)
MYD88 [endosome membrane]
(R-HSA-975123)
MYD88 [plasma membrane]
(R-HSA-937017)
MYD88 [cytosol]
(R-HSA-166059)
0.556
3
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