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2p-GLI1 [nucleoplasm]
Stable Identifier
R-HSA-5635057
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Zinc finger protein GLI1, GLI1_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
GLI proteins are phosphorylated (Homo sapiens)
2p-GLI1,2,3 [nucleoplasm] (Homo sapiens)
2p-GLI1 [nucleoplasm] (Homo sapiens)
GLI proteins bind CDC73 (Homo sapiens)
2p-GLI1,2,3 [nucleoplasm] (Homo sapiens)
2p-GLI1 [nucleoplasm] (Homo sapiens)
CDC73:2p-GLI [nucleoplasm] (Homo sapiens)
2p-GLI1,2,3 [nucleoplasm] (Homo sapiens)
2p-GLI1 [nucleoplasm] (Homo sapiens)
GLI proteins bind promoters of Hh responsive genes to promote transcription (Homo sapiens)
GLI proteins bind GLI1 gene (Homo sapiens)
2p-GLI1,2,3 [nucleoplasm] (Homo sapiens)
2p-GLI1 [nucleoplasm] (Homo sapiens)
2p-GLI:GLI1 gene [nucleoplasm] (Homo sapiens)
2p-GLI1,2,3 [nucleoplasm] (Homo sapiens)
2p-GLI1 [nucleoplasm] (Homo sapiens)
GLI proteins bind PTCH1 gene (Homo sapiens)
2p-GLI1,2,3 [nucleoplasm] (Homo sapiens)
2p-GLI1 [nucleoplasm] (Homo sapiens)
2p-GLI:PTCH1 gene [nucleoplasm] (Homo sapiens)
2p-GLI1,2,3 [nucleoplasm] (Homo sapiens)
2p-GLI1 [nucleoplasm] (Homo sapiens)
GLI1 binds HHIP gene, PTCH2 gene and BOC gene promoters (Homo sapiens)
2p-GLI1 [nucleoplasm] (Homo sapiens)
2p-GLI1:HHIP gene,PTCH2 gene,BOC gene [nucleoplasm] (Homo sapiens)
2p-GLI1 [nucleoplasm] (Homo sapiens)
Hh-dependent expression of GLI1 gene (Homo sapiens)
2p-GLI1,2,3 [nucleoplasm] (Homo sapiens)
2p-GLI1 [nucleoplasm] (Homo sapiens)
2p-GLI:GLI1 gene [nucleoplasm] (Homo sapiens)
2p-GLI1,2,3 [nucleoplasm] (Homo sapiens)
2p-GLI1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P08151 GLI1
Gene Names
GLI1, GLI
Chain
chain:1-1106
Reference Genes
BioGPS Gene:2735 GLI1
COSMIC (genes):GLI1 GLI1
CTD Gene:2735 GLI1
dbSNP Gene:2735 GLI1
ENSEMBL:ENSG00000111087 GLI1
HGNC:4317 GLI1
KEGG:hsa:2735 GLI1
Monarch:2735 GLI1
NCBI Gene:2735 GLI1
OMIM:165220 GLI1
UCSC:P08151 GLI1
Reference Transcript
RefSeq:NM_005269.2 GLI1
RefSeq:NM_001160045.1 GLI1
RefSeq:NM_001167609.1 GLI1
RefSeq:XM_011538189.2 GLI1
Participates
as a component of
2p-GLI1:HHIP gene,PTCH2 gene,BOC gene [nucleoplasm] (Homo sapiens)
as an input of
GLI1 binds HHIP gene, PTCH2 gene and BOC gene promoters (Homo sapiens)
as a member of
2p-GLI1,2,3 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
GLI1 [ciliary tip]
GLI1 [ciliary base]
p-GLI1 [nucleoplasm]
p-GLI1 [ciliary tip]
GLI1 [cytosol]
pS-GLI1 [ciliary base]
ub-pS-GLI1 [ciliary base]
ub-GLI1 [cytosol]
Inferred To
phospho-2p-GLI1 [nucleoplasm]
(Gallus gallus)
phospho-gli1 [nucleoplasm]
(Xenopus tropicalis)
phospho-Gli1 [nucleoplasm]
(Mus musculus)
phospho-Gli1 [nucleoplasm]
(Rattus norvegicus)
phospho-ci [nucleoplasm]
(Drosophila melanogaster)
phospho-GLI1 [nucleoplasm]
(Bos taurus)
phospho-GLI1 [nucleoplasm]
(Canis familiaris)
phospho-GLI1 [nucleoplasm]
(Sus scrofa)
Modified Residues
Name
phosphorylated residue at unknown position
PsiMod Name
phosphorylated residue [MOD:00696]
PsiMod Definition
A protein modification that effectively replaces a hydrogen atom with a phosphate group.
Name
phosphorylated residue at unknown position
PsiMod Name
phosphorylated residue [MOD:00696]
PsiMod Definition
A protein modification that effectively replaces a hydrogen atom with a phosphate group.
Cross References
OpenTargets
ENSG00000111087
ENSEMBL
ENSP00000441006
,
ENSG00000111087
,
ENSP00000228682
,
ENST00000228682
,
ENSP00000434408
,
ENST00000546141
,
ENST00000543426
,
ENSP00000437607
,
ENST00000528467
ZINC - Substances
GLI1_HUMAN
ZINC - Biogenic
GLI1_HUMAN
ZINC target
P08151
PRO
P08151
GlyGen
P08151
PDB
5OM0
,
4KMD
,
4BLB
,
7T91
,
2GLI
HPA
ENSG00000111087-GLI1
GeneCards
GLI1
Pharos - Targets
P08151
Orphanet
GLI1
ZINC - Predictions - Purchasable
GLI1_HUMAN
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UMX1 SUFU
3
SUFU [ciliary base]
(R-HSA-5610424)
SUFU [cytosol]
(R-HSA-445455)
SUFU [ciliary tip]
(R-HSA-5610426)
0.968
27
UniProt:Q9QZS3-2 NUMB
0.611
4
UniProt:Q96J02 ITCH
2
ITCH [cytosol]
(R-HSA-975995)
Ub-C871-ITCH [cytosol]
(R-HSA-8864515)
0.602
4
UniProt:Q9UMX1-2 SUFU
0.571
4
UniProt:Q13526 PIN1
2
PIN1 [nucleoplasm]
(R-HSA-936016)
PIN1 [cytosol]
(R-HSA-9626823)
0.556
3
UniProt:P54646 PRKAA2
4
PRKAA2 [cytosol]
(R-HSA-200405)
p-T172-PRKAA2 [cytosol]
(R-HSA-200417)
p-T172-PRKAA2 [nucleoplasm]
(R-HSA-164171)
PRKAA2 [nucleoplasm]
(R-HSA-163682)
0.556
3
UniProt:Q8NEC5 CATSPER1
1
CATSPER1 [plasma membrane]
(R-HSA-2534335)
0.556
3
UniProt:P53673 CRBA4
0.556
3
UniProt:P29972 AQP1
1
AQP1 [plasma membrane]
(R-HSA-431700)
0.556
3
UniProt:Q8IWZ5 TRI42
0.556
3
UniProt:Q96CN9 GCC1
1
GCC1 [cytosol]
(R-HSA-6813877)
0.556
3
UniProt:P23443-2 RPS6KB1
0.544
2
UniProt:Q9NRP7 STK36
0.536
2
UniProt:P46684 ZIC1
0.524
2
UniProt:P40337 VHL
3
VHL [cytosol]
(R-HSA-391423)
VHL [nucleoplasm]
(R-HSA-1234127)
monoSUMO1-K159,171,196-VHL [nucleoplasm]
(R-HSA-4551697)
0.463
2
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