GLI translocates to the nucleus

Stable Identifier
R-HSA-5635843
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Activation of SMO downstream of Hh ligand binding results in the dissociation of the SUFU:GLI complex and the translocation of the full-length GLI proteins to the nucleus where it is converted to a short-lived transcriptionally active form (Pan et al, 2006; Kim et al, 2009; Wen et al, 2010; Humke et al, 2010; Tukachinsky et al, 2010; reviewed in Briscoe and Therond, 2013).

Participants
Participant Of
Orthologous Events