GLI proteins bind GLI1 gene

Stable Identifier
R-HSA-5635846
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
GLI proteins bind GLI1 gene
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
GLI1 is a direct target of the GLI transcription factors and its expression is absolutely dependent on Hh pathway activation (Dai et al, 1999; Bai et al, 2002; Bai et al, 2004; Vokes et al, 2007; Vokes et al, 2008; Lee et al, 2010). GLI1 is an obligate transcriptional activator and its expression downstream of Hh stimulation establishes a positive feedback loop (reviewed in Briscoe and Therond, 2013).
Literature References
PubMed ID Title Journal Year
14723851 All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3

Stephen, D, Joyner, AL, Bai, CB

Dev. Cell 2004
10075717 Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3

Ishii, S, Dai, P, Nakafuku, M, Maekawa, T, Akimaru, H, Tanaka, Y

J. Biol. Chem. 1999
17442700 Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning

Davidson, EH, Giles, S, Wong, WH, Longabaugh, WJ, McCuine, S, McMahon, AP, Ji, H, Tenzen, T, Vokes, SA, Zhong, S

Development 2007
18832070 A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb

Wong, WH, McMahon, AP, Ji, H, Vokes, SA

Genes Dev. 2008
23719536 The mechanisms of Hedgehog signalling and its roles in development and disease

Thérond, PP, Briscoe, J

Nat. Rev. Mol. Cell Biol. 2013
12361967 Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway

Stephen, D, Joyner, AL, Auerbach, W, Bai, CB, Lee, JS

Development 2002
20460306 Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis

Wong, WH, McMahon, AP, Ji, H, Scott, MP, Lee, EY, Vokes, SA, Ma, W, Ouyang, Z, Zhou, B

Proc. Natl. Acad. Sci. U.S.A. 2010
Participants
Input
Output
Participates
as an event of
Authored
Rothfels, K  (2014-10-31)
Reviewed
Liu, Y C  (2014-11-09)
Created
Rothfels, K  (2014-11-07)
Cite Us!