GLI proteins bind GLI1 gene

Stable Identifier
R-HSA-5635846
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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GLI1 is a direct target of the GLI transcription factors and its expression is absolutely dependent on Hh pathway activation (Dai et al, 1999; Bai et al, 2002; Bai et al, 2004; Vokes et al, 2007; Vokes et al, 2008; Lee et al, 2010). GLI1 is an obligate transcriptional activator and its expression downstream of Hh stimulation establishes a positive feedback loop (reviewed in Briscoe and Therond, 2013).

Literature References
PubMed ID Title Journal Year
10075717 Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3

Dai, P, Akimaru, H, Tanaka, Y, Maekawa, T, Nakafuku, M, Ishii, S

J. Biol. Chem. 1999
14723851 All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3

Bai, CB, Stephen, D, Joyner, AL

Dev. Cell 2004
17442700 Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning

Vokes, SA, Ji, H, McCuine, S, Tenzen, T, Giles, S, Zhong, S, Longabaugh, WJ, Davidson, EH, Wong, WH, McMahon, AP

Development 2007
18832070 A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb

Vokes, SA, Ji, H, Wong, WH, McMahon, AP

Genes Dev. 2008
23719536 The mechanisms of Hedgehog signalling and its roles in development and disease

Briscoe, J, Thérond, PP

Nat. Rev. Mol. Cell Biol. 2013
12361967 Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway

Bai, CB, Auerbach, W, Lee, JS, Stephen, D, Joyner, AL

Development 2002
20460306 Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis

Lee, EY, Ji, H, Ouyang, Z, Zhou, B, Ma, W, Vokes, SA, McMahon, AP, Wong, WH, Scott, MP

Proc. Natl. Acad. Sci. U.S.A. 2010
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