Reactome: A Curated Pathway Database

NUMB:ITCH binds GLI1

Stable Identifier
R-HSA-5635861
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

GLI1 is recruited to the NUMB:ITCH complex through a direct interaction with both proteins. Once recruited, GLI1 is ubiquitinated by ITCH and subsequently degraded by the proteasome. ITCH-mediated degradation of GLI1 does not depend on the Dc or Dn degrons required for interaction with beta-TrCP, but instead relies on a novel PPXYs/pSP degron of GLI1 (di Marcotullio et al, 2006, 2011; Huntzicker et al, 2006).

Literature References
Participants
Participant Of
Orthologous Events