Reactome: A Curated Pathway Database

ub-GLI is degraded by the proteasome

Stable Identifier
R-HSA-5635868
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

After NUMB:ITCH-mediated ubiquitination, GLI1 is degraded by the proteasome. This degradation limits the extent and duration of the response to Hh signaling (di Marcotullio et al, 2006; Huntzicker et al, 2006; di Marcotullio et al, 2011).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
endopeptidase activity of 26S proteasome [cytosol] 26S proteasome [cytosol] endopeptidase activity (0004175)
Orthologous Events