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ub-GLI is degraded by the proteasome

Stable Identifier
R-HSA-5635868
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

After NUMB:ITCH-mediated ubiquitination, GLI1 is degraded by the proteasome. This degradation limits the extent and duration of the response to Hh signaling (di Marcotullio et al, 2006; Huntzicker et al, 2006; di Marcotullio et al, 2011).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
endopeptidase activity of 26S proteasome [cytosol]
Physical Entity
Activity
Orthologous Events