PLC-gamma 1 binds to p-EGFRvIII mutant

Stable Identifier
R-HSA-5637792
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, extracellular region, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PLC-gamma 1 binds to p-EGFRvIII mutant
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Tyrosine residue Y992 (corresponding to Y1016 when counting from the first amino acid of the EGFR precursor, prior to cleavage of the 24-amino acid signal peptide at the N-terminus), a docking site for PLC-gamma 1 (PLCG1), is phosphorylated in EGFRvIII cancer mutant and expected to recruit PLC-gamma 1 in the same way as the wild-type EGFR receptor (Grandal et al. 2007).
Literature References
PubMed ID Title Journal Year
17372273 EGFRvIII escapes down-regulation due to impaired internalization and sorting to lysosomes

Zandi, R, Willumsen, BM, Poulsen, HS, Pedersen, MW, van Deurs, B, Grandal, MV

Carcinogenesis 2007
Participants
Input
Output
Participates
as an event of
Normal reaction
Phospholipase C-gamma1 binds to the activated EGF receptor (Homo sapiens)
Functional status

Gain of function of p-5Y-EGFRvIII mutant dimer [plasma membrane]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Orlic-Milacic, M  (2011-11-04)
Reviewed
Greulich, H  (2011-11-15)
Savas, S  (2011-11-15)
Created
Orlic-Milacic, M  (2014-11-13)
Cite Us!