Phosphorylation of SHC1 by p-5Y-EGFRvIII

Stable Identifier
R-HSA-5637796
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
ReviewStatus
5/5
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Phosphorylation of SHC1 by p-5Y-EGFRvIII
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EGFRvIII cancer mutant was not directly tested for its ability to phosphorylate SHC1, but is assumed to interact with SHC1 in the same way as the wild-type EGFR protein (Soler et al. 1994, VanderKuur et al. 1995).
Literature References
PubMed ID Title Journal Year
7535773 Growth hormone-promoted tyrosyl phosphorylation of SHC proteins and SHC association with Grb2

Carter-Su, C, Allevato, G, Norstedt, G, Billestrup, N, VanderKuur, J

J Biol Chem 1995
8036006 Potent SHC tyrosine phosphorylation by epidermal growth factor at low receptor density or in the absence of receptor autophosphorylation sites

Alvarez, CV, Soler, C, Beguinot, L, Carpenter, G

Oncogene 1994
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of p-5Y-EGFRvIII:SHC1 [plasma membrane]

Physical Entity
p-5Y-EGFRvIII:SHC1 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Normal reaction
SHC1 phosphorylation by phosphorylated EGFR (Homo sapiens)
Functional status

Gain of function of p-5Y-EGFRvIII:SHC1 [plasma membrane]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Orlic-Milacic, M  (2011-11-04)
Reviewed
Greulich, H  (2011-11-15)
Savas, S  (2011-11-15)
Created
Orlic-Milacic, M  (2014-11-13)
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