SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII)

Stable Identifier
R-HSA-5637806
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Based on the wild-type EGFR signaling, it is assumed that the guanine nucleotide exchange factor SOS1 interacts with phosphorylated EGFRvIII mutant through the adaptor protein, GRB2. Upon formation of this complex, SOS1 activates RAS by promoting GDP release and GTP binding. Although this reaction has not been directly confirmed for EGFRvIII cancer mutant, RAS-MAPK signaling cascade is activated in cells expressing EGFRvIII (Montgomery et al.1995).

Literature References
PubMed ID Title Journal Year
8530489 Differential modulation of mitogen-activated protein (MAP) kinase/extracellular signal-related kinase kinase and MAP kinase activities by a mutant epidermal growth factor receptor

Montgomery, RB, Moscatello, DK, Wong, AJ, Cooper, JA, Stahl, WL

J. Biol. Chem. 1995
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
Ras guanyl-nucleotide exchange factor activity of p-5Y-EGFRvIII:GRB2:SOS1 [plasma membrane]
Physical Entity
Activity
Normal reaction
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created