Reactome | RP2 activates the GTPase activity of ARL3

RP2 activates the GTPase activity of ARL3

Stable Identifier

R-HSA-5638007

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cilium

ReviewStatus

5/5

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RP2 activates the GTPase activity of ARL3

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RP2 is an ARL3 GAP that is localized to the cilium and plays a role in trafficking proteins from the Golgi to the ciliary membrane (Veltel et al, 2008a; Hurd et al, 2011; Evans et al, 2010; Wright et al, 2011). RP2 forms a ternary complex with UNC119B and ARL3, activating the ARL3 GTPase activity and promoting the release of UNC119B (Veltel et al, 2008b; Wright et al, 2011; Kuhnel et al, 2006; reviewed in Schwarz et al, 2012; Li et al, 2012)

Literature References

PubMed ID	Title	Journal	Year
20106869	The retinitis pigmentosa protein RP2 links pericentriolar vesicle transport between the Golgi and the primary cilium Evans, RJ, Schwarz, N, Nagel-Wolfrum, K, Wolfrum, U, Hardcastle, AJ, Cheetham, ME	Hum. Mol. Genet.	2010
16472755	Crystal structure of the human retinitis pigmentosa 2 protein and its interaction with Arl3 Kühnel, K, Veltel, S, Schlichting, I, Wittinghofer, A	Structure	2006
18376416	The retinitis pigmentosa 2 gene product is a GTPase-activating protein for Arf-like 3 Veltel, S, Gasper, R, Eisenacher, E, Wittinghofer, A	Nat. Struct. Mol. Biol.	2008
21285245	Localization of retinitis pigmentosa 2 to cilia is regulated by Importin beta2 Hurd, TW, Fan, S, Margolis, BL	J. Cell. Sci.	2011
22389062	The emerging role of Arf/Arl small GTPases in cilia and ciliopathies Li, Y, Ling, K, Hu, J	J. Cell. Biochem.	2012
22085962	An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium Wright, KJ, Baye, LM, Olivier-Mason, A, Mukhopadhyay, S, Sang, L, Kwong, M, Wang, W, Pretorius, PR, Sheffield, VC, Sengupta, P, Slusarski, DC, Jackson, PK	Genes Dev.	2011
18588884	Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3-effector-GAP complex Veltel, S, Kravchenko, A, Ismail, S, Wittinghofer, A	FEBS Lett.	2008
22884633	Arl3 and RP2 mediated assembly and traffic of membrane associated cilia proteins Schwarz, N, Hardcastle, AJ, Cheetham, ME	Vision Res.	2012