CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body

Stable Identifier
R-HSA-5638009
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

The distal appendage protein CEP164 interacts with RAB3IP, and in this way recruits Golgi-derived vesicles to the basal body to initiate ciliary membrane biogenesis (Schmidt et al, 2012; Westlake et al, 2011; Rohatgi and Snell, 2010). RAB3IP recruitment to the distal appendages of centrioles promotes the appropriate localization and activation of RAB8A (Nachury et al, 2007; Yoshimura et al, 2007; Westlake et al, 2011; Schmidt et al, 2012).

Literature References
PubMed ID Title Journal Year
17646400 Functional dissection of Rab GTPases involved in primary cilium formation

Yoshimura, S, Egerer, J, Fuchs, E, Haas, AK, Barr, FA

J. Cell Biol. 2007
23253480 Cep164 mediates vesicular docking to the mother centriole during early steps of ciliogenesis

Schmidt, KN, Kuhns, S, Neuner, A, Hub, B, Zentgraf, H, Pereira, G

J. Cell Biol. 2012
20399632 The ciliary membrane

Rohatgi, R, Snell, WJ

Curr. Opin. Cell Biol. 2010
21273506 Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome

Westlake, CJ, Baye, LM, Nachury, MV, Wright, KJ, Ervin, KE, Phu, L, Chalouni, C, Beck, JS, Kirkpatrick, DS, Slusarski, DC, Sheffield, VC, Scheller, RH, Jackson, PK

Proc. Natl. Acad. Sci. U.S.A. 2011
17574030 A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis

Nachury, MV, Loktev, AV, Zhang, Q, Westlake, CJ, Peränen, J, Merdes, A, Slusarski, DC, Scheller, RH, Bazan, JF, Sheffield, VC, Jackson, PK

Cell 2007
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