PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27)

Stable Identifier
R-HSA-5638332
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3
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EZH2 (KMT6, PRC2) is the catalytic subunit of the PRC2 (EZH2) Core complex, which additionally contains EED, SUZ12, AEBP2 and one of RBBP4 or RBBP7. It methylates lysine-28 (H3K27) of histone H3 (Cao et al. 2002, Czermin et al. 2002, Kuzmichev et al. 2002, Muller et al. 2002) leading to transcriptional repression of the affected target gene. It is able to mono-, di- and trimethylate lysine-28 (Cao & Zhang 2004).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
histone-lysine N-methyltransferase activity of PRC2 (EZH2) Core:AEBP2 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created