WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27)

Stable Identifier
R-HSA-5638333
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
WHSC1 methylates lysine-28 of histone H3
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WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27)
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WHSC1 (KMT3G, MMSET) is able to mono-, di- and trimethylate lysine-28 (Kim et al. 2008).

Literature References
PubMed ID Title Journal Year
18172012 Multiple-myeloma-related WHSC1/MMSET isoform RE-IIBP is a histone methyltransferase with transcriptional repression activity

Kim, JY, Kee, HJ, Choe, NW, Kim, SM, Eom, GH, Baek, HJ, Kook, H, Kook, H, Seo, SB

Mol. Cell. Biol. 2008
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
histone-lysine N-methyltransferase activity of WHSC1, WHSC1L1 [nucleoplasm]
Physical Entity
WHSC1, WHSC1L1 [nucleoplasm]
Activity
histone-lysine N-methyltransferase activity (0018024)
Orthologous Events
WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Bos taurus)
WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Caenorhabditis elegans)
WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Canis familiaris)
WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Dictyostelium discoideum)
WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Mus musculus)
WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Rattus norvegicus)
WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Sus scrofa)
Authored
Jupe, S  (2014-11-13)
Reviewed
Motamedi, M  (2014-11-17)
Created
Jupe, S  (2014-11-13)