Reactome | PNKP [nucleoplasm]

PNKP [nucleoplasm]

Stable Identifier

R-HSA-5649651

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Bifunctional polynucleotide phosphatase/kinase, PNK

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q96T60 PNKP

Gene Names

PNKP

Chain

chain:1-521

Reference Genes

BioGPS Gene:11284 PNKP

COSMIC (genes):PNKP PNKP

CTD Gene:11284 PNKP

dbSNP Gene:11284 PNKP

ENSEMBL:ENSG00000039650 PNKP

ENSEMBL_homo_sapiens_GENE:ENSG00000039650.12 PNKP

HGNC:9154 PNKP

KEGG Gene (Homo sapiens):11284 PNKP

Monarch:11284 PNKP

NCBI Gene:11284 PNKP

OMIM:605610 PNKP

UCSC:Q96T60 PNKP

Reference Transcript

RefSeq:NM_007254.3 PNKP

Other Identifiers

11284

11744073_a_at

16874401

218961_PM_s_at

218961_s_at

3868126

3868127

3868129

3868131

3868133

3868135

3868137

3868138

3868139

3868140

3868141

3868142

3868144

3868146

3868148

3868149

3868152

3868156

3868157

3868158

8038458

A_33_P3402918

GE58448

GO:0000166

GO:0003677

GO:0003684

GO:0003690

GO:0003824

GO:0004519

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0006260

GO:0006261

GO:0006281

GO:0006287

GO:0006289

GO:0006303

GO:0006974

GO:0006979

GO:0008152

GO:0009314

GO:0010836

GO:0016020

GO:0016301

GO:0016310

GO:0016740

GO:0016787

GO:0017076

GO:0032200

GO:0032212

GO:0035861

GO:0043226

GO:0046403

GO:0046404

GO:0051103

GO:0051734

GO:0051973

GO:1904355

GO:2001034

HMNXSV003015996

ILMN_1694111

PH_hs_0004504

TC19001727.hg

g6005835_3p_a_at

Participates

as an output of

LIG3:XRCC1, POLB, NEIL1,NEIL2 and PNKP dissociate from the BER site (Homo sapiens)

as an input of

LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA (Homo sapiens)

as a component of

Inferred To

Ghost homologue of PNKP [nucleoplasm] (Xenopus tropicalis)

Pnkp [nucleoplasm] (Rattus norvegicus)

pnkp [nucleoplasm] (Danio rerio)

PNKP [nucleoplasm] (Bos taurus)

PNKP [nucleoplasm] (Canis familiaris)

PNKP [nucleoplasm] (Dictyostelium discoideum)

PNKP [nucleoplasm] (Mus musculus)

PNKP [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_009185.2

OpenTargets

ENSG00000039650

IntEnz

2.7.1.78

GeneCards

Q96T60

HPA

ENSG00000039650-PNKP

Ensembl

ENSP00000323511, ENSP00000472300, ENST00000596014, ENST00000322344, ENSG00000039650

PRO

Q96T60

Pharos - Targets

Q96T60

Orphanet

19137

HMDB Protein

HMDBP01284

PDB

2W3O, 2BRF

Interactors (49)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13426 XRCC4	2	monoSUMO1-K210-XRCC4 [nucleoplasm] (R-HSA-4568892) XRCC4 [nucleoplasm] (R-HSA-75911)	0.942	18
UniProt:P18887 XRCC1	1	XRCC1 [nucleoplasm] (R-HSA-67455)	0.832	8
UniProt:O94972 TRIM37	1	TRIM37 [cytosol] (R-HSA-976049)	0.739	6
UniProt:Q15025 TNIP1	1	TNIP1 [cytosol] (R-HSA-5690853)	0.718	6
UniProt:Q9UID6 ZN639			0.718	6
UniProt:O43829 ZBT14			0.718	6
UniProt:P49916 LIG3	1	LIG3 [nucleoplasm] (R-HSA-53789)	0.564	3
IntAct:EBI-23221822 CCSB ORF ID			0.556	3
UniProt:P22607 FGFR3	20	FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 805fs*141 [plasma membrane] (R-HSA-1614387) FGFR3 [plasma membrane] (R-HSA-2038357) FGFR3 S371C [plasma membrane] (R-HSA-1614421) FGFR3 Y373C [plasma membrane] (R-HSA-1614424) FGFR3 G370C [plasma membrane] (R-HSA-1614394) FGFR3 R248C [plasma membrane] (R-HSA-1614419)	0.556	3
UniProt:Q02446 SP4			0.556	3
UniProt:Q53G59 KLHL12	1	KLHL12 [cytosol] (R-HSA-1504203)	0.556	3
UniProt:Q8WW34-2 TMEM239			0.556	3
UniProt:Q9NS64 RPRM			0.556	3
UniProt:Q8N137 CNTRB			0.556	3
UniProt:Q8WV19 SFT2A			0.556	3
UniProt:O60749 SNX2	2	SNX2 [Golgi membrane] (R-HSA-434333) SNX2 [cytoplasmic vesicle membrane] (R-HSA-434216)	0.556	3
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.556	3
UniProt:Q13554-3 CAMK2B			0.556	3
UniProt:Q9NVV9 THAP1			0.556	3
UniProt:O43586 PSTPIP1	1	PSTPIP1 [cytosol] (R-HSA-879220)	0.556	3
UniProt:Q8NCY6 MSD4			0.556	3
UniProt:P28329-3 P283293			0.556	3
UniProt:Q13422 IKZF1			0.556	3
UniProt:Q99735 MGST2	1	MGST2 [endoplasmic reticulum membrane] (R-HSA-176058)	0.556	3
UniProt:Q9UGQ2 FLOWR			0.556	3
UniProt:Q8N9I5 FADS6			0.556	3
UniProt:Q96PV4 PNMA5			0.556	3
UniProt:Q9BWT7 CAR10			0.556	3
UniProt:O43759-2 SYNGR1			0.556	3
UniProt:Q63ZY3 KANK2			0.556	3
UniProt:Q6FHY5 Q6FHY5			0.556	3
UniProt:Q86WV7 Q86WV7			0.556	3
UniProt:Q13422-7 IKZF1			0.556	3
UniProt:Q49A88-3 CCDC14			0.556	3
UniProt:P08247 SYP	1	SYP [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-5215991)	0.556	3
UniProt:Q92997 DVL3	4	pp-DVL3 [cytosol] (R-HSA-3772400) p-DVL3 [cytosol] (R-HSA-201680) DVL3 [cytosol] (R-HSA-201678) ub-DVL3 [cytosol] (R-HSA-4652688)	0.556	3
UniProt:P23508 CRCM			0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:Q9UMD9 COL17A1	20	GlcGalHyl-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2173102) GalHyl-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2173084) 3x4Hyp-GlcGalHyl-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2173190) 3x4Hyp-3Hyp-GalHyl-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2173237) 3x4Hyp-GalHyl-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2173184) 3x4Hyp-3Hyp-GlcGalHyl-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2173264) 3x4Hyp-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2172934) 3x4Hyp-3Hyp-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2172989) 3x4Hyp-5Hyl-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2173162) 3x4Hyp-3Hyp-5Hyl-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2173230) 5Hyl-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2173044) 3x4Hyp-GalHyl-COL17A1(?-1497) [extracellular region] (R-HSA-2471866) 5Hyl-COL17A1(?-1497) [extracellular region] (R-HSA-2471851) 3x4Hyp-3Hyp-COL17A1(?-1497) [extracellular region] (R-HSA-2471867) 3x4Hyp-5Hyl-COL17A1(?-1497) [extracellular region] (R-HSA-2471913) 3x4Hyp-3Hyp-5Hyl-COL17A1(?-1497) [extracellular region] (R-HSA-2471897) COL17A1(?-1497) [extracellular region] (R-HSA-2471870) GalHyl-COL17A1(?-1497) [extracellular region] (R-HSA-2471903) 3x4Hyp-3Hyp-GlcGalHyl-COL17A1(?-1497) [extracellular region] (R-HSA-2471916) 3x4Hyp-COL17A1(?-1497) [extracellular region] (R-HSA-2471874)	0.556	3
UniProt:O95995 GAS8	1	GAS8 [cytosol] (R-HSA-5633057)	0.556	3
UniProt:Q15633 TARBP2	2	TARBP2 [cytosol] (R-HSA-203864) p-TARBP2 [cytosol] (R-HSA-9835348)	0.556	3
UniProt:Q86TI0 TBC1D1	2	TBC1D1 [cytoplasmic vesicle membrane] (R-HSA-1454718) p-S237-TBC1D1 [cytosol] (R-HSA-1454673)	0.556	3
UniProt:Q8N5K1 CISD2			0.556	3
UniProt:O43761 SNG3			0.556	3
UniProt:Q96MW1 CCD43			0.527	2
UniProt:P69905 HBA1	4	CO-H+-HBA1 [cytosol] (R-HSA-1237026) HBA1 [cytosol] (R-HSA-1008268) HBA1 [endocytic vesicle lumen] (R-HSA-2230966) HBA1 [extracellular region] (R-HSA-2168862)	0.527	2
UniProt:P06746 POLB	2	PolyUb-POLB [nucleoplasm] (R-HSA-6783152) POLB [nucleoplasm] (R-HSA-53845)	0.527	2
UniProt:P68871 HBB	8	CO-H+-HBB [cytosol] (R-HSA-1237013) HBB [ficolin-1-rich granule lumen] (R-HSA-6801015) HBB [tertiary granule lumen] (R-HSA-6800191) HBB [endocytic vesicle lumen] (R-HSA-2230936) HBB [extracellular region] (R-HSA-2168872) HBB [late endosome lumen] (R-HSA-9631108) HBB [cytosol] (R-HSA-1008196) HBB [lysosomal lumen] (R-HSA-9625193)	0.527	2
UniProt:O43524 FOXO3	11	p-S215 FOXO3 [nucleoplasm] (R-HSA-5687010) p-S215 FOXO3 [cytosol] (R-HSA-5687014) FOXO3 [cytosol] (R-HSA-5687032) p-S43,S173,S294,S325-FOXO3 [nucleoplasm] (R-HSA-8870627) p-S43,S173,S294,S325-FOXO3 [cytosol] (R-HSA-8870560) FOXO3(?-673) [mitochondrial matrix] (R-HSA-9841824) Ac-K271,K290-FOXO3(?-673) [mitochondrial matrix] (R-HSA-9841849) Ac-K242,K259,K271,K290,K569-FOXO3 [nucleoplasm] (R-HSA-9620514) p-T32,S253,S315-FOXO3 [cytosol] (R-HSA-9614413) p-T32,S253,S315-FOXO3 [nucleoplasm] (R-HSA-199289) FOXO3 [nucleoplasm] (R-HSA-199305)	0.499	2

Cite Us!