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DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79)

Stable Identifier
R-HSA-5649801
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
DOT1L methylates lysine-80 of histone H3
Locations in the PathwayBrowser
Summation

DOT1L is capable of catalyzing mono-, di-, and trimethylation in a nonprocessive manner (Min et al. 2003, Frederiks et al. 2008). It appear to be solely responsible for H3K79 methylation, since knockout of Dot1 in yeast, flies and mice results in complete loss of H3K79 methylation (van Leeuwen et al. 2002, Shanower et al. 2005, Jones et al. 2008).

Literature References
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
histone-lysine N-methyltransferase activity of DOT1L [nucleoplasm]
Physical Entity
Activity
Orthologous Events