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Me2K80-HIST2H3A [nucleoplasm]
Stable Identifier
R-HSA-5649803
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
PKMTs methylate histone lysines (Homo sapiens)
DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) (Homo sapiens)
Me2K80-histone H3 [nucleoplasm] (Homo sapiens)
Me2K80-HIST2H3A [nucleoplasm] (Homo sapiens)
DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) (Homo sapiens)
Me2K80-histone H3 [nucleoplasm] (Homo sapiens)
Me2K80-HIST2H3A [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q71DI3 H3C15
Gene Names
H3C15, HIST2H3A, H3C14, H3F2, H3FM, HIST2H3C, H3C13, HIST2H3D
Chain
chain:1-136
Reference Genes
BioGPS Gene:126961 H3C15
BioGPS Gene:333932 H3C15
BioGPS Gene:653604 H3C15
CTD Gene:126961 H3C15
CTD Gene:333932 H3C15
CTD Gene:653604 H3C15
dbSNP Gene:126961 H3C15
dbSNP Gene:333932 H3C15
dbSNP Gene:653604 H3C15
ENSEMBL:ENSG00000183598 HIST2H3D
ENSEMBL:ENSG00000203811 HIST2H3C
ENSEMBL:ENSG00000203852 HIST2H3A
ENSEMBL_homo_sapiens_GENE:ENSG00000183598.4 H3C15
ENSEMBL_homo_sapiens_GENE:ENSG00000203811.2 H3C15
ENSEMBL_homo_sapiens_GENE:ENSG00000203852.4 H3C15
HGNC:20503 H3C15
HGNC:20505 H3C15
HGNC:25311 H3C15
KEGG Gene (Homo sapiens):126961 H3C15
KEGG Gene (Homo sapiens):333932 H3C15
KEGG Gene (Homo sapiens):653604 H3C15
Monarch:126961 H3C15
Monarch:333932 H3C15
Monarch:653604 H3C15
NCBI Gene:126961 H3C15
NCBI Gene:333932 H3C15
NCBI Gene:653604 H3C15
OMIM:142780 H3C15
UCSC:Q71DI3 H3C15
Reference Transcript
RefSeq:NM_001123375.2 H3C15
RefSeq:NM_001005464.2 H3C15
RefSeq:NM_021059.2 H3C15
Other Identifiers
11742410_s_at
126961
16670387
16692614
16692616
2357939
2357940
2434047
2434082
2434083
333932
653604
7905085
7919589
7919612
7919614
ADDON002755.hg
ADDON002789.hg
A_23_P115375
A_24_P324465
A_24_P45651
A_33_P3257678
GE79559
GO:0000786
GO:0003677
GO:0005198
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005694
GO:0006325
GO:0006334
GO:0030527
GO:0043226
GO:0043229
GO:0046982
GO:0065003
GO:0070062
HMNXSV003021896
HMNXSV003029395
ILMN_1664706
ILMN_1666179
PH_hs_0030802
PH_hs_0034534
TC01001175.hg
TC01003173.hg
TC01003188.hg
TC01003189.hg
Participates
as a candidate of
Me2K80-histone H3 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
2xAcK-HIST2H3A [nucleoplasm]
Me1K5-HIST2H3A [nucleoplasm]
Me2aR27-HIST2H3A [nucleoplasm]
Me2aR18-HIST2H3A [nucleoplasm]
Me2sR9-HIST2H3A [nucleoplasm]
Me2sR3-HIST2H3A [nucleoplasm]
AcK9,14-p-S10-HIST2H3A [nucleoplasm]
AcK14,18,79-p-S10-HIST2H3A [nucleoplasm]
AcK9,14,18-p-S10,T11-HIST2H3A [nucleoplasm]
AcK14,18-p-S10,T11-HIST2H3A [nucleoplasm]
AcK9,14,18,79-p-S10,T11-HIST2H3A [nucleoplasm]
AcK14,18-p-S10-HIST2H3A [nucleoplasm]
AcK14,18,79-p-T11-HIST2H3A [nucleoplasm]
AcK14,18-p-T11-HIST2H3A [nucleoplasm]
AcK14,18,79-p-S10,T11-HIST2H3A [nucleoplasm]
Me2K28-HIST2H3A [nucleoplasm]
MeK37-HIST2H3A [nucleoplasm]
MeK80-HIST2H3A [nucleoplasm]
Me3K80-HIST2H3A [nucleoplasm]
Me3K37-HIST2H3A [nucleoplasm]
Me2K37-HIST2H3A [nucleoplasm]
MeK-HIST2H3A [nucleoplasm]
MeK28-HIST2H3A [nucleoplasm]
MeK10-HIST2H3A [cytosol]
HIST2H3A [cytosol]
Me2aR3-HIST2H3A [nucleoplasm]
MeK5-HIST2H3A [nucleoplasm]
Cit27-HIST2H3A [nucleoplasm]
Cit3-HIST2H3A [nucleoplasm]
Cit9-HIST2H3A [nucleoplasm]
Cit18-HIST2H3A [nucleoplasm]
MeR18-HIST2H3A [nucleoplasm]
MeR3-HIST2H3A [nucleoplasm]
MeR27-HIST2H3A [nucleoplasm]
MeR9-HIST2H3A [nucleoplasm]
Me2K5,Me2aR3-HIST2H3A [nucleoplasm]
Ack10-HIST2H3A [nucleoplasm]
HIST2H3A [extracellular region]
AcK24-HIST2H3A [nucleoplasm]
Ack15-HIST2H3A [nucleoplasm]
AcK19-HIST2H3A [nucleoplasm]
AcK5-HIST2H3A [nucleoplasm]
Me2K10-HIST2H3A [nucleoplasm]
p-T12-HIST2H3A [nucleoplasm]
p-T12,MeK-HIST2H3A [nucleoplasm]
p-T12, Me2K-10-HIST2H3A [nucleoplasm]
p-T12, Me3K-10-HIST2H3A [nucleoplasm]
Me3K10-HIST2H3A [nucleoplasm]
Me3K5-HIST2H3A [nucleoplasm]
Me3K28-HIST2H3A [nucleoplasm]
HIST2H3A [nucleoplasm]
Me2K5-HIST2H3A [nucleoplasm]
Inferred To
H3C15 [nucleoplasm]
(Sus scrofa)
H3c4 [nucleoplasm]
(Mus musculus)
cnp1 [nucleoplasm]
(Schizosaccharomyces pombe)
Me2K80-HIST1H3A [nucleoplasm]
(Plasmodium falciparum)
Me2K80-HIST2H3A [nucleoplasm]
(Bos taurus)
Homologues of Me2K80-HIST1H3A [nucleoplasm]
(Plasmodium falciparum)
H3a [nucleoplasm]
(Dictyostelium discoideum)
CSE4 [nucleoplasm]
(Saccharomyces cerevisiae)
hcp-3 [nucleoplasm]
(Caenorhabditis elegans)
Hist2h3c2 [nucleoplasm]
(Rattus norvegicus)
Modified Residues
Name
N6,N6-dimethyl-L-lysine at 80
Coordinate
80
PsiMod Name
N6,N6-dimethyl-L-lysine [MOD:00084]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6,N6-dimethyl-L-lysine.
Cross References
RefSeq
NP_001116847.1
,
NP_066403.2
,
NP_001005464.1
OpenTargets
ENSG00000203852
HPA
ENSG00000183598-H3C13
,
ENSG00000203852-H3C15
,
ENSG00000203811-H3C14
GeneCards
Q71DI3
Ensembl
ENST00000331491
,
ENST00000403683
,
ENST00000369158
,
ENSP00000333277
,
ENSG00000183598
,
ENSP00000385479
,
ENSP00000358154
,
ENSG00000203852
,
ENSG00000203811
PRO
Q71DI3
Pharos - Targets
Q71DI3
PDB
7TAN
,
7U51
,
7PEX
,
7U50
,
5CIU
,
2IIJ
,
7PF0
,
3QO2
,
7PEY
,
3R93
,
7PEV
,
7UVA
,
7JOA
,
3DB3
,
6FML
,
7PEW
,
7PFX
,
7PET
,
7PF4
,
7PFF
,
2X4X
,
7PEU
,
7PF5
,
8AV6
,
7PFE
,
2X4W
,
7PEZ
,
7BU9
,
6Y5D
,
7PF2
,
7PF3
,
5BO0
,
3AV1
,
2X4Y
,
5VAC
,
7XCR
,
7PFT
,
4OUC
,
6X5A
,
6T79
,
7XCT
,
7PFA
,
7PFU
,
6T7C
,
6T7D
,
5B0Y
,
4MZG
,
5B0Z
,
8ATF
,
6X59
,
4MZF
,
7PF6
,
7UV9
,
7JO9
,
7JZV
,
6T7B
,
8AAG
,
6Y5E
,
4MZH
,
7BQZ
,
6ACE
,
8JLB
,
7PFV
,
8OL1
,
7U53
,
3MO8
,
7U52
,
5B40
,
8JLD
,
8GRQ
,
7XD0
,
7PFD
,
7PFC
,
6XJD
,
7YRD
,
6T7A
,
7PFW
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62805 H4C1
17
polySUMO3-HIST1H4 [nucleoplasm]
(R-HSA-4570531)
monoSUMO1-HIST1H4 [nucleoplasm]
(R-HSA-4570518)
4xAcK-HIST1H4A [nucleoplasm]
(R-HSA-427390)
AcK5,12-HIST1H4A [nucleoplasm]
(R-HSA-212078)
AcK13-HIST1H4 [nucleoplasm]
(R-HSA-4568744)
Me2aR4-HIST1H4 [nucleoplasm]
(R-HSA-5229015)
Me2sR4-HIST1H4 [nucleoplasm]
(R-HSA-4754243)
MeR4-HIST1H4 [nucleoplasm]
(R-HSA-4754240)
Me3K21-HIST1H4 [nucleoplasm]
(R-HSA-5651656)
HIST1H4A [extracellular region]
(R-HSA-977569)
AcK17-HIST1H4 [nucleoplasm]
(R-HSA-427469)
AcK6-HIST1H4 [nucleoplasm]
(R-HSA-4568748)
AcK9-HIST1H4 [nucleoplasm]
(R-HSA-4568758)
MeK21-HIST1H4 [nucleoplasm]
(R-HSA-5423110)
AcK-HIST1H4 [nucleoplasm]
(R-HSA-3451124)
Me2K21-HIST1H4 [nucleoplasm]
(R-HSA-5651652)
HIST1H4 [nucleoplasm]
(R-HSA-181902)
0.704
4
UniProt:Q9Y294 ASF1A
1
ASF1A [nucleoplasm]
(R-HSA-417169)
0.576
4
UniProt:P49736 MCM2
1
MCM2 [nucleoplasm]
(R-HSA-68557)
0.576
5
UniProt:Q96CV9 OPTN
6
OPTN [recycling endosome membrane]
(R-HSA-8854141)
p-S177-OPTN [nucleoplasm]
(R-HSA-2562595)
p-S177-OPTN [cytosol]
(R-HSA-2562525)
OPTN [Golgi membrane]
(R-HSA-2161111)
OPTN [cytosol]
(R-HSA-9687907)
p-S177,S473,S513-OPTN [cytosol]
(R-HSA-9687840)
0.556
3
UniProt:P19404 NDUFV2
1
NDUFV2 [mitochondrial inner membrane]
(R-HSA-163939)
0.556
3
UniProt:P29474 NOS3
9
2xPalmC-MyrG-p-S1177,S1179-NOS3 [plasma membrane]
(R-HSA-9860783)
2xPalmC-MyrG-p-S633-NOS3 [plasma membrane]
(R-HSA-9861341)
2xPalmC-MyrG-NOS3 [endocytic vesicle membrane]
(R-HSA-535007)
2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane]
(R-HSA-202139)
MyrG-NOS3 [Golgi membrane]
(R-HSA-534995)
MyrG-NOS3 [cytosol]
(R-HSA-203687)
2xPalmC-MyrG-NOS3 [plasma membrane]
(R-HSA-534993)
2xPalmC-MyrG-NOS3 [Golgi membrane]
(R-HSA-203769)
NOS3 [cytosol]
(R-HSA-202114)
0.556
3
UniProt:P37840 SNCA
5
SNCA A30P [cytosol]
(R-HSA-5658569)
SNCA [extracellular region]
(R-HSA-976954)
Ub-SNCA [cytosol]
(R-HSA-5660754)
p-S129-SNCA [cytosol]
(R-HSA-9836432)
SNCA [cytosol]
(R-HSA-5658500)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
18
UniProt:P14136 GFAP
3
p-GFAP [lysosomal membrane]
(R-HSA-9626054)
GFAP [lysosomal membrane]
(R-HSA-9625195)
GFAP [cytosol]
(R-HSA-1253311)
0.556
3
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