SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20)

Stable Identifier
R-HSA-5651654
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
SUV420H1, SUV420H2, (SMYD3) methylate methyl-lysine-21 of histone H4 (H4K20), SUV420H1, SUV420H2, (SMYD3) methylate Me2K21-histone H4 (H4K20), SUV420H1, SUV420H2, (SMYD3) methylate Me2K21-histone H4
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The di- and tri-methylation of lysine-21 of histone H4 (H4K20) are performed by SUV420H1 (KMT5B), SUV420H2 (KMT5C) and possibly SMYD3 (KMT3E) (Foreman et al. 2011). Trimethylation is associated with heterochromatin formation and gene repression (Schotta et al. 2004). Monomethylation is performed by SETD8 (KMT5A) (Yin et al. 2005).

Literature References
PubMed ID Title Journal Year
15145825 A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin

Schotta, G, Lachner, M, Sarma, K, Ebert, A, Sengupta, R, Reuter, G, Reinberg, D, Jenuwein, T

Genes Dev. 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
histone-lysine N-methyltransferase activity of SUV420H1,SUV420H2,(SMYD3) [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created