Reactome: A Curated Pathway Database

FEN1 bound to POLB cleaves displaced DNA strand (flap)

Stable Identifier
R-HSA-5651782
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

POLB-bound FEN1 (flap endonuclease) cleaves the displaced DNA strand (flap structure), which contains the damaged AP residue that could not be excised by POLB (DNA polymerase beta) (Klungland and Lindahl 1997, Prasad et al. 2001, Liu et al. 2005).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
5'-flap endonuclease activity of FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] 5'-flap endonuclease activity (0017108)