The ubiquitin ligase complex RBX1:CUL4:DDB1:DTL can also monoubiquitinate PCNA. RBX1:CUL4:DDB1:DTL is probably responsible for the basal monoubiquitination of PCNA and may contribute to the kinetics of DNA-damage induced PCNA monoubiquitination (Terai et al. 2010).
Nielsen, ML, Poulsen, SL, Sylvestersen, KB, Beli, P, Choudhary, C, Povlsen, LK, Bekker-Jensen, S, Mailand, N, Poulsen, JW, Wagner, SA
Friedberg, EC, Lehmann, AR, Fuchs, RP
Moldovan, GL, Hoege, C, Pfander, B, Pyrowolakis, G, Jentsch, S
Lee, SW, Seol, JH, Yang, SW, Yu, KR, Park, JM, Ka, SH, Jeon, YJ, Chung, CH
Abbas, T, Dutta, A, Terai, K, Jazaeri, AA
ubiquitin-protein transferase activity of RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm]
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