Reactome | Fructose metabolism

Fructose metabolism

Stable Identifier

R-HSA-5652084

DOI

10.3180/r-hsa-5652084.2

Type

Pathway

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Fructose is found in fruits, is one of the components of the disaccharide sucrose, and is a widely used sweetener in processed foods. Dietary fructose is catabolized in the liver via fructose 1-phosphate to yield dihydroxyacetone phosphate and glyceraldehyde 3-phosphate, which then are converted to pyruvate via steps of canonical glycolysis (Hers & Kusaka 1953; Sillero et al. 1969). Excessive dietary intake of fructose and its metabolism have been associated with major disease risks in humans, although this issue remains controversial (Kolderup & Svihus 2015; DiNicolantonio et al. 2015; Bray 2013; Mayes 1993; Rippe & Angelopoulos 2013; van Buul et al. 2013). Fructose can also be synthesized from glucose via the polyol pathway (Hers 1960; Oates 2008). This synthetic process provides the fructose found in seminal fluid and, in other tissues, can contribute to pathologies of diabetes.

Literature References

PubMed ID	Title	Journal	Year
23493540	Sucrose, high-fructose corn syrup, and fructose, their metabolism and potential health effects: what do we really know? Rippe, JM, Angelopoulos, TJ	Adv Nutr	2013
23493538	Energy and fructose from beverages sweetened with sugar or high-fructose corn syrup pose a health risk for some people Bray, GA	Adv Nutr	2013
26199742	Fructose Metabolism and Relation to Atherosclerosis, Type 2 Diabetes, and Obesity Kolderup, A, Svihus, B	J Nutr Metab	2015
24666553	Misconceptions about fructose-containing sugars and their role in the obesity epidemic van Buul, VJ, Tappy, L, Brouns, FJ	Nutr Res Rev	2014
13093749	[The metabolism of fructose-1-phosphate in the liver.] Hers, HG, Kusaka, T	Biochim Biophys Acta	1953
18220710	Aldose reductase, still a compelling target for diabetic neuropathy Oates, PJ	Curr Drug Targets	2008
8213607	Intermediary metabolism of fructose Mayes, PA	Am. J. Clin. Nutr.	1993
14401391	[The mechanism of the formation of seminal fructose and fetal fructose] Hers, HG	Biochim. Biophys. Acta	1960
25639270	Added fructose: a principal driver of type 2 diabetes mellitus and its consequences DiNicolantonio, JJ, O'Keefe, JH, Lucan, SC	Mayo Clin. Proc.	2015
5823111	Enzymes involved in fructose metabolism in liver and the glyceraldehyde metabolic crossroads Sillero, MA, Sillero, A, Sols, A	Eur. J. Biochem.	1969