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LAMTOR1 [lysosomal membrane]
Stable Identifier
R-HSA-5653582
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
lysosomal membrane
Synonyms
Ragulator complex protein LAMTOR1, LTOR1_HUMAN
Icon
Locations in the PathwayBrowser for interactor UniProt:P61086 UBE2K
Expand all
Signal Transduction (Homo sapiens)
MTOR signalling (Homo sapiens)
Formation of Ragulator complex (Homo sapiens)
LAMTOR1 [lysosomal membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q6IAA8 LAMTOR1
Gene Names
LAMTOR1, C11orf59, PDRO, PP7157
Chain
initiator methionine:, chain:2-161
Reference Genes
BioGPS Gene:55004 LAMTOR1
COSMIC (genes):LAMTOR1 LAMTOR1
CTD Gene:55004 LAMTOR1
dbSNP Gene:55004 LAMTOR1
ENSEMBL:ENSG00000149357 LAMTOR1
ENSEMBL_homo_sapiens_GENE:ENSG00000149357.10 LAMTOR1
HGNC:26068 LAMTOR1
KEGG Gene (Homo sapiens):55004 LAMTOR1
Monarch:55004 LAMTOR1
NCBI Gene:55004 LAMTOR1
OMIM:613510 LAMTOR1
UCSC:Q6IAA8 LAMTOR1
Reference Transcript
RefSeq:NM_017907.2 LAMTOR1
Other Identifiers
11742925_a_at
11749390_x_at
11756743_x_at
223009_PM_at
223009_at
3380988
3380989
3380991
3380992
3380993
3380994
3380995
55004
56435_at
7950119
A_23_P2114
GE82246
GO:0001558
GO:0001919
GO:0005085
GO:0005515
GO:0005576
GO:0005615
GO:0005764
GO:0005765
GO:0005768
GO:0005773
GO:0005886
GO:0007032
GO:0007040
GO:0008104
GO:0010874
GO:0016020
GO:0016192
GO:0016197
GO:0023052
GO:0031410
GO:0031669
GO:0031902
GO:0032008
GO:0032418
GO:0035577
GO:0035579
GO:0038202
GO:0042632
GO:0043226
GO:0043410
GO:0043495
GO:0045121
GO:0051020
GO:0060090
GO:0060620
GO:0070062
GO:0071230
GO:0071986
GO:0072657
GO:0098772
GO:0101003
GO:0150032
GO:1904263
GO:1990877
HMNXSV003050438
ILMN_1815878
PH_hs_0025135
PH_hs_0035941
TC11002053.hg
g12804574_3p_at
Participates
as an input of
Formation of Ragulator complex (Homo sapiens)
as a component of
Ragulator [lysosomal membrane] (Homo sapiens)
Other forms of this molecule
LAMTOR1 [specific granule membrane]
LAMTOR1 [azurophil granule membrane]
LAMTOR1 [plasma membrane]
LAMTOR1 [ficolin-1-rich granule membrane]
Inferred To
Lamtor1 [lysosomal membrane]
(Drosophila melanogaster)
Lamtor1 [lysosomal membrane]
(Mus musculus)
Lamtor1 [lysosomal membrane]
(Rattus norvegicus)
lamtor1 [lysosomal membrane]
(Xenopus tropicalis)
Ghost homologue of LAMTOR1 [lysosomal membrane]
(Caenorhabditis elegans)
Ghost homologue of LAMTOR1 [lysosomal membrane]
(Danio rerio)
Ghost homologue of LAMTOR1 [lysosomal membrane]
(Saccharomyces cerevisiae)
Ghost homologue of LAMTOR1 [lysosomal membrane]
(Schizosaccharomyces pombe)
LAMTOR1 [lysosomal membrane]
(Bos taurus)
LAMTOR1 [lysosomal membrane]
(Canis familiaris)
LAMTOR1 [lysosomal membrane]
(Dictyostelium discoideum)
LAMTOR1 [lysosomal membrane]
(Gallus gallus)
LAMTOR1 [lysosomal membrane]
(Sus scrofa)
Cross References
RefSeq
NP_060377.1
OpenTargets
ENSG00000149357
GeneCards
Q6IAA8
HPA
ENSG00000149357-LAMTOR1
Ensembl
ENSP00000278671
,
ENST00000278671
,
ENSG00000149357
PRO
Q6IAA8
Pharos - Targets
Q6IAA8
PDB
5Y39
,
6ULG
,
6U62
,
6NZD
,
6WJ3
,
6WJ2
,
7UXH
,
7T3C
,
6B9X
,
5X6V
,
5Y3A
,
6EHR
,
5X6U
,
5YK3
,
8DHB
,
7UX2
,
7T3B
,
7UXC
,
7T3A
,
6EHP
Interactors (22)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y2Q5 LAMTOR2
5
LAMTOR2 [specific granule membrane]
(R-HSA-6800168)
LAMTOR2 [plasma membrane]
(R-HSA-6806286)
LAMTOR2 [tertiary granule membrane]
(R-HSA-6800165)
LAMTOR2 [endosome membrane]
(R-HSA-5693293)
LAMTOR2 [lysosomal membrane]
(R-HSA-5653583)
0.937
25
UniProt:Q9HB90 RRAGC
1
RRAGC [cytosol]
(R-HSA-5653949)
0.913
22
UniProt:Q0VGL1 LAMTOR4
1
LAMTOR4 [lysosomal membrane]
(R-HSA-5655432)
0.876
14
UniProt:Q9UHA4 LAMTOR3
5
LAMTOR3 [specific granule membrane]
(R-HSA-6800178)
LAMTOR3 [plasma membrane]
(R-HSA-6806307)
LAMTOR3 [tertiary granule membrane]
(R-HSA-6800189)
LAMTOR3 [endosome membrane]
(R-HSA-5693294)
LAMTOR3 [lysosomal membrane]
(R-HSA-5653581)
0.861
17
UniProt:O43504 LAMTOR5
1
LAMTOR5 [lysosomal membrane]
(R-HSA-5655441)
0.826
12
UniProt:Q7L523 RRAGA
2
K63polyUb-K142,K220,K230,K244-RRAGA [cytosol]
(R-HSA-8938830)
RRAGA [cytosol]
(R-HSA-5653577)
0.81
15
UniProt:Q5VZM2 RRAGB
1
RRAGB [cytosol]
(R-HSA-5653579)
0.788
8
UniProt:Q8NBW4 SLC38A9
1
SLC38A9 [lysosomal membrane]
(R-HSA-5215938)
0.767
15
UniProt:Q9NQL2 RRAGD
1
RRAGD [cytosol]
(R-HSA-5653953)
0.725
6
UniProt:Q9UMX0 UBQLN1
1
UBQLN1 [cytosol]
(R-HSA-8866006)
0.556
3
UniProt:P22607 FGFR3
20
FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane]
(R-HSA-8853144)
FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane]
(R-HSA-8853131)
FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane]
(R-HSA-8853152)
FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane]
(R-HSA-8853124)
FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane]
(R-HSA-8853125)
FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane]
(R-HSA-8853127)
FGFR3 K650T [plasma membrane]
(R-HSA-1614411)
FGFR3 K650N [plasma membrane]
(R-HSA-1614406)
FGFR3 K650M [plasma membrane]
(R-HSA-1614402)
FGFR3 K650Q [plasma membrane]
(R-HSA-1614410)
FGFR3 A391E [plasma membrane]
(R-HSA-1614390)
FGFR3 K650E [plasma membrane]
(R-HSA-1614400)
FGFR3 G380R [plasma membrane]
(R-HSA-1614398)
FGFR3 G382D [plasma membrane]
(R-HSA-2018740)
FGFR3 805fs*141 [plasma membrane]
(R-HSA-1614387)
FGFR3 [plasma membrane]
(R-HSA-2038357)
FGFR3 S371C [plasma membrane]
(R-HSA-1614421)
FGFR3 Y373C [plasma membrane]
(R-HSA-1614424)
FGFR3 G370C [plasma membrane]
(R-HSA-1614394)
FGFR3 R248C [plasma membrane]
(R-HSA-1614419)
0.556
3
UniProt:P06396 GSN
7
GSN(200-270) [extracellular region]
(R-HSA-976940)
GSN [secretory granule lumen]
(R-HSA-6801486)
GSN [extracellular region]
(R-HSA-6806510)
GSN [ficolin-1-rich granule lumen]
(R-HSA-6801465)
GSN(404-782) [cytosol]
(R-HSA-350272)
GSN(28-403) [cytosol]
(R-HSA-201618)
GSN [cytosol]
(R-HSA-350275)
0.556
3
UniProt:P61086 UBE2K
2
UBE2K [cytosol]
(R-HSA-934631)
Ub-C92-UBE2K [cytosol]
(R-HSA-8864200)
0.556
3
UniProt:Q9Y649 Q9Y649
0.556
3
UniProt:P78358 CTG1B
0.556
3
UniProt:P28329-3 P283293
0.556
3
UniProt:P16284 PECAM1
5
PECAM1 [platelet alpha granule membrane]
(R-HSA-61489)
PECAM1 [plasma membrane]
(R-HSA-114686)
PECAM1 [secretory granule membrane]
(R-HSA-6804778)
p-Y663,Y686-PECAM1(27-?) [plasma membrane]
(R-HSA-210007)
p-Y713-PECAM1 [plasma membrane]
(R-HSA-9860772)
0.556
3
UniProt:P20339 RAB5A
7
GGC-RAB5A [clathrin-coated endocytic vesicle membrane]
(R-HSA-8871125)
GGC-RAB5A [early endosome membrane]
(R-HSA-8875323)
GGC-RAB5A [cytosol]
(R-HSA-8870432)
RAB5A [early endosome membrane]
(R-HSA-2130175)
RAB5A [cytosol]
(R-HSA-2201187)
GGC-RAB5A [macropinosome membrane]
(R-HSA-9837697)
RAB5A [endosome membrane]
(R-HSA-452257)
0.556
3
UniProt:P08670 VIM
11
VIM(2-85) [cytosol]
(R-HSA-350264)
VIM(86-466) [cytosol]
(R-HSA-350294)
VIM(430-466) [cytosol]
(R-HSA-350316)
VIM(2-429) [cytosol]
(R-HSA-350317)
VIM(260-466) [cytosol]
(R-HSA-350314)
VIM(2-259) [cytosol]
(R-HSA-350323)
VIM [cytosol]
(R-HSA-201600)
Vimentin [late endosome lumen]
(R-HSA-9660019)
Vimentin [microtubule organizing center]
(R-HSA-9657898)
Vimentin [cytosol]
(R-HSA-9646687)
Vimentin [lysosomal lumen]
(R-HSA-9659977)
0.556
3
UniProt:Q8N122 RPTOR
3
RPTOR [nucleoplasm]
(R-HSA-5083664)
RPTOR [cytosol]
(R-HSA-3006727)
p-S722,S792-RPTOR [cytosol]
(R-HSA-3132767)
0.527
2
UniProt:Q96GS4 BORC6
0.527
5
UniProt:Q6IAA8 LAMTOR1
5
LAMTOR1 [specific granule membrane]
(R-HSA-6799631)
LAMTOR1 [lysosomal membrane]
(R-HSA-5653582)
LAMTOR1 [azurophil granule membrane]
(R-HSA-6799633)
LAMTOR1 [plasma membrane]
(R-HSA-6806270)
LAMTOR1 [ficolin-1-rich granule membrane]
(R-HSA-6801003)
0.471
2
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