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K168-PCNA-G157-ISG15 [nucleoplasm]
Stable Identifier
R-HSA-5653744
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Icon
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
DNA Damage Bypass (Homo sapiens)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Homo sapiens)
Termination of translesion DNA synthesis (Homo sapiens)
UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA (Homo sapiens)
DNA polymerase Y:MonoUb:K164,ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164,ISG:K164,ISG:K168-PCNA homotrimer [nucleoplasm] (Homo sapiens)
ISG:K164,ISG:K168-PCNA [nucleoplasm] (Homo sapiens)
K168-PCNA-G157-ISG15 [nucleoplasm] (Homo sapiens)
USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Homo sapiens)
DNA polymerase Y:MonoUb:K164,ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164,ISG:K164,ISG:K168-PCNA homotrimer [nucleoplasm] (Homo sapiens)
ISG:K164,ISG:K168-PCNA [nucleoplasm] (Homo sapiens)
K168-PCNA-G157-ISG15 [nucleoplasm] (Homo sapiens)
USP10:DNA polymerase Y:MonoUb:K164,ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
DNA polymerase Y:MonoUb:K164,ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164,ISG:K164,ISG:K168-PCNA homotrimer [nucleoplasm] (Homo sapiens)
ISG:K164,ISG:K168-PCNA [nucleoplasm] (Homo sapiens)
K168-PCNA-G157-ISG15 [nucleoplasm] (Homo sapiens)
USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Homo sapiens)
ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
ISG:K164,ISG:K168-PCNA homotrimer [nucleoplasm] (Homo sapiens)
ISG:K164,ISG:K168-PCNA [nucleoplasm] (Homo sapiens)
K168-PCNA-G157-ISG15 [nucleoplasm] (Homo sapiens)
USP10:DNA polymerase Y:MonoUb:K164,ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
DNA polymerase Y:MonoUb:K164,ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164,ISG:K164,ISG:K168-PCNA homotrimer [nucleoplasm] (Homo sapiens)
ISG:K164,ISG:K168-PCNA [nucleoplasm] (Homo sapiens)
K168-PCNA-G157-ISG15 [nucleoplasm] (Homo sapiens)
USP43 binds ISG:K164,ISG:K168-PCNA (Homo sapiens)
ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
ISG:K164,ISG:K168-PCNA homotrimer [nucleoplasm] (Homo sapiens)
ISG:K164,ISG:K168-PCNA [nucleoplasm] (Homo sapiens)
K168-PCNA-G157-ISG15 [nucleoplasm] (Homo sapiens)
USP43:ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
ISG:K164,ISG:K168-PCNA homotrimer [nucleoplasm] (Homo sapiens)
ISG:K164,ISG:K168-PCNA [nucleoplasm] (Homo sapiens)
K168-PCNA-G157-ISG15 [nucleoplasm] (Homo sapiens)
USP43 deISGylates ISG:K164,ISG:K168-PCNA (Homo sapiens)
USP43:ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
ISG:K164,ISG:K168-PCNA homotrimer [nucleoplasm] (Homo sapiens)
ISG:K164,ISG:K168-PCNA [nucleoplasm] (Homo sapiens)
K168-PCNA-G157-ISG15 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P05161 ISG15
Gene Names
ISG15, G1P2, UCRP
Chain
initiator methionine:1, chain:2-157, propeptide:158-165
Reference Genes
BioGPS Gene:9636 ISG15
COSMIC (genes):ISG15 ISG15
CTD Gene:9636 ISG15
dbSNP Gene:9636 ISG15
ENSEMBL:ENSG00000187608 ISG15
HGNC:4053 ISG15
KEGG Gene (Homo sapiens):9636 ISG15
Monarch:9636 ISG15
NCBI Gene:9636 ISG15
OMIM:147571 ISG15
UCSC:P05161 ISG15
Reference Transcript
RefSeq:NM_005101.3 ISG15
Other Identifiers
0004590398
1107_s_at
11716895_s_at
16657594
205483_s_at
38432_at
4053544
4053545
4053546
4053547
4053548
4053549
7896817
9636
A_23_P819
GE62795
GO:0002376
GO:0003674
GO:0005178
GO:0005515
GO:0005575
GO:0005576
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005840
GO:0006259
GO:0006464
GO:0006950
GO:0007165
GO:0007229
GO:0008150
GO:0009056
GO:0009058
GO:0009617
GO:0016032
GO:0019899
GO:0019941
GO:0019985
GO:0022627
GO:0030154
GO:0030501
GO:0031386
GO:0031397
GO:0031625
GO:0032020
GO:0032480
GO:0032609
GO:0032613
GO:0032649
GO:0032991
GO:0034340
GO:0034641
GO:0042592
GO:0042742
GO:0043226
GO:0044403
GO:0045071
GO:0045087
GO:0045648
GO:0048856
GO:0051607
GO:0060337
HMNXSV003047646
ILMN_1813289
ILMN_2054019
M13755_at
PH_hs_0028539
TC01000023.hg
g4826773_3p_a_at
Participates
as a component of
ISG:K164,ISG:K168-PCNA [nucleoplasm] (Homo sapiens)
Other forms of this molecule
ISG15 [nucleoplasm]
ISG15 [cytosol]
K164-PCNA-G157-ISG15 [nucleoplasm]
Inferred To
RPL40A [nucleoplasm]
(Saccharomyces cerevisiae)
Isg15 [nucleoplasm]
(Mus musculus)
Isg15 [nucleoplasm]
(Rattus norvegicus)
uep1 [nucleoplasm]
(Schizosaccharomyces pombe)
ubi1 [nucleoplasm]
(Schizosaccharomyces pombe)
isg15 [nucleoplasm]
(Danio rerio)
Homologues of K164-PCNA-G157-ISG15 [nucleoplasm]
(Saccharomyces cerevisiae)
Homologues of K164-PCNA-G157-ISG15 [nucleoplasm]
(Schizosaccharomyces pombe)
ISG15 [nucleoplasm]
(Bos taurus)
ISG15 [nucleoplasm]
(Canis familiaris)
ISG15 [nucleoplasm]
(Sus scrofa)
K164-PCNA-G157-ISG15 [nucleoplasm]
(Caenorhabditis elegans)
RPL40B [nucleoplasm]
(Saccharomyces cerevisiae)
Ghost homologue of K168-PCNA-G157-ISG15 [nucleoplasm]
(Drosophila melanogaster)
Ghost homologue of K168-PCNA-G157-ISG15 [nucleoplasm]
(Gallus gallus)
Ghost homologue of K168-PCNA-G157-ISG15 [nucleoplasm]
(Plasmodium falciparum)
Modified Residues
Name
Inter-chain Crosslink via N6-glycyl-L-lysine at 157 and 168
Coordinate
157
PsiMod Name
N6-glycyl-L-lysine
PsiMod Definition
A protein modification that effectively crosslinks an L-lysine residue and a glycine residue by an isopeptide bond to form N6-glycyl-L-lysine.
Cross References
RefSeq
NP_005092.1
Target Pathogen
5b354852be737e166372ee3b
OpenTargets
ENSG00000187608
GeneCards
P05161
HPA
ENSG00000187608-ISG15
Ensembl
ENST00000649529
,
ENSG00000187608
,
ENSP00000496832
PRO
P05161
Orphanet
21556
PDB
3SDL
,
5W8T
,
6XA9
,
2HJ8
,
3RT3
,
5W8U
,
1Z2M
,
3PSE
,
6BI8
,
5TL6
,
3PHX
,
3R66
,
6FFA
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UMW8 USP18
1
USP18 [cytosol]
(R-HSA-912325)
0.873
9
UniProt:P41226 UBA7
2
UBA7 [cytosol]
(R-HSA-936550)
UBA7 [nucleoplasm]
(R-HSA-5653762)
0.836
10
UniProt:Q6TQR6 L
0.743
5
UniProt:P0C6U8-PRO_0000338257
0.719
5
UniProt:P03502 NS1
0.65
4
UniProt:P0DTD1-PRO_0000449621 REP
0.618
4
UniProt:K0BWD0 K0BWD0
0.618
4
UniProt:P03495 NS1
0.602
4
UniProt:O75369 FLNB
1
FLNB [cytosol]
(R-HSA-354163)
0.591
4
UniProt:O75688 PPM1B
1
PPM1B [cytosol]
(R-HSA-1169375)
0.558
2
UniProt:O60260-5 PRKN
0.556
3
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