Reactome | TRIM25 binds monoUb:164-PCNA

TRIM25 binds monoUb:164-PCNA

Stable Identifier

R-HSA-5653756

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

EFP binds monoubiquitinated PCNA

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PCNA monoubiquitinated on lysine residue K164 (MonoUb:K164-PCNA) is bound by ISG15 E3 ligase TRIM25 (EFP) in complex with ISG15 E2 conjugating enzyme UBE2L6 (UBCH8) (Park et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
24768535	Modification of PCNA by ISG15 plays a crucial role in termination of error-prone translesion DNA synthesis Park, JM, Yang, SW, Yu, KR, Ka, SH, Lee, SW, Seol, JH, Jeon, YJ, Chung, CH	Mol. Cell	2014