USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA

Stable Identifier
R-HSA-5653766
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Ubiquitin protease USP10 binds doubly ISGylated and monoubiquitinated PCNA (Park et al. 2014). PCNA exists as a homotrimer so that the ISGylation and monoubiquitination occur on different subunits.

Literature References
PubMed ID Title Journal Year
24768535 Modification of PCNA by ISG15 plays a crucial role in termination of error-prone translesion DNA synthesis

Park, JM, Yang, SW, Yu, KR, Ka, SH, Lee, SW, Seol, JH, Jeon, YJ, Chung, CH

Mol. Cell 2014
Participants
Participant Of
Orthologous Events
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