USP43 deISGylates ISG:K164,ISG:K168-PCNA

Stable Identifier
R-HSA-5653786
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
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USP43 acts as an ISG15 protease to cleave ISG15 from lysines K164 and K168 of PCNA, thus deISGylating PCNA (Park et al. 2014).

Literature References
PubMed ID Title Journal Year
24768535 Modification of PCNA by ISG15 plays a crucial role in termination of error-prone translesion DNA synthesis

Park, JM, Yang, SW, Yu, KR, Ka, SH, Lee, SW, Seol, JH, Jeon, YJ, Chung, CH

Mol. Cell 2014
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ISG15-specific protease activity of USP43:ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created