POLD,POLE binds deISGylated PCNA after TLS

Stable Identifier
R-HSA-5653838
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Once deubiquitinated and deISGylated, PCNA can again associate with the catalytic subunit POLD1 of replicative DNA polymerase delta complex (POLD), or presumably POLE of DNA polymerase epsilon complex (POLE) (Park et al. 2014). Double monoubiquitination of PCNA-associated protein KIAA0101 (PAF15) facilitates the switch from translesion DNA synthesis (TLS) polymerases to replicative DNA polymerases POLD or POLE (Povlsen et al. 2012).

Literature References
PubMed ID Title Journal Year
24768535 Modification of PCNA by ISG15 plays a crucial role in termination of error-prone translesion DNA synthesis

Park, JM, Yang, SW, Yu, KR, Ka, SH, Lee, SW, Seol, JH, Jeon, YJ, Chung, CH

Mol. Cell 2014
23000965 Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass

Povlsen, LK, Beli, P, Wagner, SA, Poulsen, SL, Sylvestersen, KB, Poulsen, JW, Nielsen, ML, Bekker-Jensen, S, Mailand, N, Choudhary, C

Nat. Cell Biol. 2012
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This event is regulated
Orthologous Events
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