Ragulator:Rag dimers:SLC38A9 bind mTORC1

Stable Identifier
R-HSA-5653968
Type
Reaction [binding]
Species
Homo sapiens
Compartment
lysosomal membrane, cytosol
ReviewStatus
5/5
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Ragulator:Rag dimers:SLC38A9 bind mTORC1
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The Ragulator complex on the lysosomal surface binds Rag heterodimers which in turn bind mTORC1 (Sancak et al. 2010).
Literature References
PubMed ID Title Journal Year
20381137 Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

Sabatini, DM, Zoncu, R, Sancak, Y, Bar-Peled, L, Nada, S, Markhard, AL

Cell 2010
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Orthologous Events
Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Bos taurus)
Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Caenorhabditis elegans)
Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Canis familiaris)
Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Danio rerio)
Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Dictyostelium discoideum)
Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Drosophila melanogaster)
Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Gallus gallus)
Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Mus musculus)
Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Rattus norvegicus)
Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Sus scrofa)
Authored
Jupe, S  (2015-02-02)
Reviewed
Zwartkruis, FJ  (2015-05-14)
Created
Jupe, S  (2014-12-03)
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