Ragulator:Rag dimers:SLC38A9 bind mTORC1

Stable Identifier
R-HSA-5653968
Type
Reaction [binding]
Species
Homo sapiens
Compartment
lysosomal membrane, cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Ragulator:Rag dimers:SLC38A9 bind mTORC1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The Ragulator complex on the lysosomal surface binds Rag heterodimers which in turn bind mTORC1 (Sancak et al. 2010).

Literature References
PubMed ID Title Journal Year
20381137 Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

Sabatini, DM, Zoncu, R, Sancak, Y, Bar-Peled, L, Nada, S, Markhard, AL

Cell 2010
Participants
Input
Output
Participates
as an event of
Orthologous Events
Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Bos taurus)
Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Caenorhabditis elegans)
Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Canis familiaris)
Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Danio rerio)
Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Dictyostelium discoideum)
Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Drosophila melanogaster)
Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Gallus gallus)
Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Mus musculus)
Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Rattus norvegicus)
Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Sus scrofa)
Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Xenopus tropicalis)
Authored
Jupe, S  (2015-02-02)
Reviewed
Zwartkruis, FJ  (2015-05-14)
Created
Jupe, S  (2014-12-03)
Cite Us!