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mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane]
Stable Identifier
R-HSA-5653972
Type
Complex
Species
Homo sapiens
Compartment
lysosomal membrane
Synonyms
Ragulator:Rag:GNP heterodimers:mTORC1
Locations in the PathwayBrowser
Expand all
Autophagy (Homo sapiens)
Macroautophagy (Homo sapiens)
Active MTORC1 binds the ULK1 complex (Homo sapiens)
MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Homo sapiens)
MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
Active MTORC1 phosphorylates ULK1 (Homo sapiens)
MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Homo sapiens)
MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
MTORC1:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Homo sapiens)
MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
Rheb in the MTORC1 complex hydrolyses GTP (Homo sapiens)
MTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Homo sapiens)
MTORC1:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Homo sapiens)
MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Metabolic Genes (Homo sapiens)
RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Homo sapiens)
Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
PTEN Regulation (Homo sapiens)
Regulation of PTEN gene transcription (Homo sapiens)
MAF1 translocates to the nucleus (Homo sapiens)
MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
mTORC1 phosphorylates MAF1 (Homo sapiens)
MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
MTOR signalling (Homo sapiens)
AKT1S1 (PRAS40) binds mTORC1 (Homo sapiens)
Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Homo sapiens)
Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Homo sapiens)
mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Homo sapiens)
Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Homo sapiens)
Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
Energy dependent regulation of mTOR by LKB1-AMPK (Homo sapiens)
AMPK phosphorylates Raptor in the mTORC1 complex (Homo sapiens)
Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Homo sapiens)
Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
Formation of active mTORC1 complex (Homo sapiens)
Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
Phosphorylated AKT1S1:mTORC1 binds YWHAB (Homo sapiens)
mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Homo sapiens)
Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Homo sapiens)
mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Homo sapiens)
Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
mTORC1 phosphorylates AKT1S1 (Homo sapiens)
mTORC1:RHEB:GTP:p-S183,T246-AKT1S1:YWHAB [lysosomal membrane] (Homo sapiens)
mTORC1:RHEB:GTP:p-S183,T246-AKT1S1 [lysosomal membrane] (Homo sapiens)
Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Homo sapiens)
mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Homo sapiens)
Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
mTORC1-mediated signalling (Homo sapiens)
Phosphorylation of 4E-BP1 by activated mTORC1 (Homo sapiens)
Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Homo sapiens)
Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Homo sapiens)
mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Homo sapiens)
Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
mTORC1 phosphorylation of RPS6KB1 (S6K) (Homo sapiens)
Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Homo sapiens)
mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Homo sapiens)
Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
Participants
components
mTORC1 [cytosol]
(Homo sapiens)
Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane]
(Homo sapiens)
Participates
as an output of
Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Homo sapiens)
as a component of
mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Homo sapiens)
Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
MTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Homo sapiens)
MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Homo sapiens)
as an input of
Formation of active mTORC1 complex (Homo sapiens)
Inferred To
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane]
(Bos taurus)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane]
(Caenorhabditis elegans)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane]
(Canis familiaris)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane]
(Danio rerio)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane]
(Dictyostelium discoideum)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane]
(Drosophila melanogaster)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane]
(Gallus gallus)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane]
(Mus musculus)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane]
(Rattus norvegicus)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane]
(Sus scrofa)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane]
(Xenopus tropicalis)
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