Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange

Stable Identifier
R-HSA-5654413
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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SOS, recruited by GRB2:p-FRS2 to activated FGFR, activates RAS nucleotide exchange from the inactive GDP-bound to the active GTP-bound state.

Literature References
PubMed ID Title Journal Year
8493579 Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2

Chardin, P, Camonis, JH, Gale, NW, Van Aelst, L, Schlessinger, J, Wigler, MH, Bar-Sagi, D

Science 1993
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
Ras guanyl-nucleotide exchange factor activity of Activated FGFR3:p-FRS:GRB2:SOS1 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created