Activated FGFR1:p-SHC1 binds GRB2:SOS1

Stable Identifier
R-HSA-5654597
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Phosphorylated SHC1 links FGFR to Grb2 (Klint et al. 1995) leading to the formation of a signaling complex including Shc, Grb2 and Sos. Transformation of NIH 3T3 cells with v-Src produced a strong constitutive association of FGFR1 with Shc, Grb2 and Sos (Curto et al. 1998) suggesting Src involvement. Recruitment of Grb2-Sos links FGFR to the Ras pathway.

Literature References
PubMed ID Title Journal Year
7559490 Shc and a novel 89-kDa component couple to the Grb2-Sos complex in fibroblast growth factor-2-stimulated cells

Klint, P, Kanda, S, Claesson-Welsh, L

J Biol Chem 1995
9480847 Novel recruitment of Shc, Grb2, and Sos by fibroblast growth factor receptor-1 in v-Src-transformed cells

Curto, M, Frankel, P, Carrero, A, Foster, DA

Biochem Biophys Res Commun 1998
9045692 Signal transduction pathway of human fibroblast growth factor receptor 3. Identification of a novel 66-kDa phosphoprotein.

Kanai, M, Goke, M, Tsunekawa, S, Podolsky, DK

J Biol Chem 1997
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