FRS3 (also known as FRS2beta) is predominantly expressed in the developing and adult neuroepithelium. As is the case for FRS2 (also known as FRS2alpha), binding of FRS3 to FGFR may be constitutive and/or independent of receptor activation. Elements of the downstream signaling mediated by the two FRS family members appear to be at least partially conserved, as FRS3 is phosphorylated upon FGF stimulation, binds PPTN11/SHP2 and GRB2 and results in ERK activation. Moreover, expression of FRS3 in FRS2-/- MEFs restores ERK activation.
Ong, SH, Guy, GR, Hadari, YR, Laks, S, Gotoh, N, Schlessinger, J, Lax, I
Xu, H, Lee, KW, Goldfarb, M
Minegishi, Y, Iwanari, H, Mochizuki, Y, Horii, T, Hoshino, T, Kodama, T, Hamakubo, T, Gotoh, N
Gotoh, N, Laks, S, Nakashima, M, Lax, I, Schlessinger, J
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