Activated FGFR2 binds FRS3

Stable Identifier
R-HSA-5654603
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, extracellular region, plasma membrane
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Activated FGFR2 binds FRS3
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FRS3 (also known as FRS2beta) is predominantly expressed in the developing and adult neuroepithelium. As is the case for FRS2 (also known as FRS2alpha), binding of FRS3 to FGFR may be constitutive and/or independent of receptor activation. Elements of the downstream signaling mediated by the two FRS family members appear to be at least partially conserved, as FRS3 is phosphorylated upon FGF stimulation, binds PPTN11/SHP2 and GRB2 and results in ERK activation. Moreover, expression of FRS3 in FRS2-/- MEFs restores ERK activation.

Literature References
PubMed ID Title Journal Year
10629055 FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors

Ong, SH, Guy, GR, Hadari, YR, Laks, S, Gotoh, N, Schlessinger, J, Lax, I

Mol Cell Biol 2000
9660748 Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins

Xu, H, Lee, KW, Goldfarb, M

J Biol Chem 1998
19187780 Prominent expression of FRS2beta protein in neural cells and its association with intracellular vesicles

Minegishi, Y, Iwanari, H, Mochizuki, Y, Horii, T, Hoshino, T, Kodama, T, Hamakubo, T, Gotoh, N

FEBS Lett 2009
15094036 FRS2 family docking proteins with overlapping roles in activation of MAP kinase have distinct spatial-temporal patterns of expression of their transcripts

Gotoh, N, Laks, S, Nakashima, M, Lax, I, Schlessinger, J

FEBS Lett 2004
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Authored
Rothfels, K  (2011-08-15)
Reviewed
Gotoh, N  (2011-08-26)
Created
Rothfels, K  (2014-12-03)