Activated FGFR2 phosphorylates FRS3

Stable Identifier
R-HSA-5654605
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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FRS3 (also known as FRS2 beta) is activated through tyrosine phosphorylation catalyzed by the protein kinase domain of the activated FGFR. By sequence comparison, FRS3 has the 2 PPTN11/SHP2-binding sites and has three of the four GRB2-binding sites.

Literature References
PubMed ID Title Journal Year
9182757 A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway

Kouhara, H, Hadari, YR, Spivak-Kroizman, T, Schilling, J, Bar-Sagi, D, Lax, I, Schlessinger, J

Cell 1997
12419216 The docking protein FRS2alpha controls a MAP kinase-mediated negative feedback mechanism for signaling by FGF receptors

Lax, I, Wong, A, Lamothe, B, Lee, A, Frost, A, Hawes, J, Schlessinger, J

Mol Cell 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of Activated FGFR2:FRS3 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created