Activated FGFR2:pFRS binds GRB2:SOS1

Stable Identifier
R-HSA-5654615
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Tyrosine phosphorylated FRS2 recruits GRB2:SOS1 complex by means of the SH3 domain of GRB2, leading to RAS-MAP kinase activation. The FRS2:GRB2-mediated pathway plays a minor role in the activation of RAS-MAP kinase pathway compared to that mediated by FRS2:PPTN11.

Literature References
PubMed ID Title Journal Year
7559490 Shc and a novel 89-kDa component couple to the Grb2-Sos complex in fibroblast growth factor-2-stimulated cells

Klint, P, Kanda, S, Claesson-Welsh, L

J Biol Chem 1995
9182757 A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway

Kouhara, H, Hadari, YR, Spivak-Kroizman, T, Schilling, J, Bar-Sagi, D, Lax, I, Schlessinger, J

Cell 1997
11353842 Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins

Ong, SH, Hadari, YR, Gotoh, N, Guy, GR, Schlessinger, J, Lax, I

Proc Natl Acad Sci U S A 2001
11447289 Critical role for the docking-protein FRS2 alpha in FGF receptor-mediated signal transduction pathways

Hadari, YR, Gotoh, N, Kouhara, H, Lax, I, Schlessinger, J

Proc Natl Acad Sci U S A 2001
8780727 Suc1-associated neurotrophic factor target (SNT) protein is a major FGF-stimulated tyrosine phosphorylated 90-kDa protein which binds to the SH2 domain of GRB2

Ong, SH, Goh, KC, Lim, YP, Low, BC, Klint, P, Claesson-Welsh, L, Cao, X, Tan, YH, Guy, GR

Biochem Biophys Res Commun 1996
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