PI-3K cascade:FGFR1

Stable Identifier
R-HSA-5654689
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

The ability of growth factors to protect from apoptosis is primarily due to the activation of the AKT survival pathway. P-I-3-kinase dependent activation of PDK leads to the activation of AKT which in turn affects the activity or expression of pro-apoptotic factors, which contribute to protection from apoptosis. AKT activation also blocks the activity of GSK-3b which could lead to additional antiapoptotic signals.

Literature References
PubMed ID Title Journal Year
10918587 Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4

Hart, KC, Robertson, SC, Kanemitsu, MY, Meyer, AN, Tynan, JA, Donoghue, DJ

Oncogene 2000
12558974 The role of phosphatidylinositol 3-kinase in neural cell adhesion molecule-mediated neuronal differentiation and survival

Ditlevsen, DK, Kohler, LB, Pedersen, MV, Risell, M, Kolkova, K, Meyer, M, Berezin, V, Bock, E

J Neurochem 2003
11057895 Cell signaling by receptor tyrosine kinases

Schlessinger, J

Cell 2000
15863030 Cellular signaling by fibroblast growth factor receptors

Eswarakumar, VP, Lax, I, Schlessinger, J

Cytokine Growth Factor Rev 2005
12089343 The phosphatidylinositol 3-kinase/Akt signaling pathway modulates the endocrine differentiation of trophoblast cells

Kamei, T, Jones, SR, Chapman, BM, MCGonigle, KL, Dai, G, Soares, MJ

Mol Endocrinol 2002
Participants
Participant Of
Orthologous Events
Authored
Reviewed