p-CBL:GRB2 binds p-FRS2:activated FGFR2

Stable Identifier
R-HSA-5654729
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The ubiquitin ligase CBL exists in a complex with GRB2 and is recruited to tyrosine-phosphorylated FRS2 after FGF stimulation. In addition to promoting the ubiquitination, endocytosis, and degradation of the activated receptor complex, recruitment of the p-CBL:GRB2 complex seems to attenuate FGFR signaling by competing with GRB2:SOS1 for binding to the direct GRB2-binding sites on p-FRS2.

Literature References
PubMed ID Title Journal Year
11997436 FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl

Wong, A, Lamothe, B, Lee, A, Schlessinger, J, Lax, I

Proc Natl Acad Sci U S A 2002
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