Negative regulation of FGFR3 signaling

Stable Identifier
R-HSA-5654732
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Once activated, the FGFR signaling pathway is regulated by numerous negative feedback mechanisms. These include downregulation of receptors through CBL-mediated ubiquitination and endocytosis, ERK-mediated inhibition of FRS2-tyrosine phosphorylation and the attenuation of ERK signaling through the action of dual-specificity phosphatases, IL17RD/SEF, Sprouty and Spred proteins. A number of these inhibitors are themselves transcriptional targets of the activated FGFR pathway.

Literature References
PubMed ID Title Journal Year
12815057 Tyrosine phosphorylation of Sprouty2 enhances its interaction with c-Cbl and is crucial for its function

Fong, CW, Leong, HF, Wong, ES, Lim, J, Yusoff, P, Guy, GR

J Biol Chem 2003
20940169 Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease

Itoh, N, Ornitz, DM

J Biochem 2011
11997436 FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl

Wong, A, Lamothe, B, Lee, A, Schlessinger, J, Lax, I

Proc Natl Acad Sci U S A 2002
18452557 Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins

Gotoh, N

Cancer Sci 2008
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