Reactome: A Curated Pathway Database

Negative regulation of FGFR4 signaling

Stable Identifier
R-HSA-5654733
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Once activated, the FGFR signaling pathway is regulated by numerous negative feedback mechanisms. These include downregulation of receptors through CBL-mediated ubiquitination and endocytosis, ERK-mediated inhibition of FRS2-tyrosine phosphorylation and the attenuation of ERK signaling through the action of dual-specificity phosphatases, IL17RD/SEF, Sprouty and Spred proteins. A number of these inhibitors are themselves transcriptional targets of the activated FGFR pathway.

Literature References
Participants
Participant Of
Orthologous Events