SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH

Stable Identifier
R-HSA-5654985
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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SPRTN (Spartan, C1orf124, DVC1) contains a SHP box that binds the hexameric AAA-ATPase VCP (p97). SPRTN recruits VCP, in complex with VCP adaptors NPLOC4 and UFD1L, to monoubiquitinated PCNA (MonoUb:K164-PCNA) associated with POLH at DNA damage sites (Ghosal et al. 2012, Davis et al. 2012, Mosbech et al. 2012).

Literature References
PubMed ID Title Journal Year
23042605 DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks

Mosbech, A, Gibbs-Seymour, I, Kagias, K, Thorslund, T, Beli, P, Povlsen, L, Nielsen, SV, Smedegaard, S, Sedgwick, G, Lukas, C, Hartmann-Petersen, R, Lukas, J, Choudhary, C, Pocock, R, Bekker-Jensen, S, Mailand, N

Nat. Struct. Mol. Biol. 2012
23042607 DVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA damage

Davis, EJ, Lachaud, C, Appleton, P, Macartney, TJ, Näthke, I, Rouse, J

Nat. Struct. Mol. Biol. 2012
22902628 Proliferating cell nuclear antigen (PCNA)-binding protein C1orf124 is a regulator of translesion synthesis

Ghosal, G, Leung, JW, Nair, BC, Fong, KW, Chen, J

J. Biol. Chem. 2012
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